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Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection

Although the etiology of Kawasaki disease (KD) remains elusive, the available evidence indicates that the primum movens may be a dysregulated immune response to various microbial agents, leading to cytokine cascade and endothelial cell activation in patients with KD. Documented infections by differe...

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Autor principal: Rigante, Donato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340244/
https://www.ncbi.nlm.nih.gov/pubmed/32670517
http://dx.doi.org/10.4084/MJHID.2020.039
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author Rigante, Donato
author_facet Rigante, Donato
author_sort Rigante, Donato
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description Although the etiology of Kawasaki disease (KD) remains elusive, the available evidence indicates that the primum movens may be a dysregulated immune response to various microbial agents, leading to cytokine cascade and endothelial cell activation in patients with KD. Documented infections by different viruses in many individual cases have been largely reported and are discussed herein, but attempts to demonstrate their causative role in the distinctive KD scenario and KD epidemiological features have been disappointing. To date, no definite link has been irrefutably found between a single infection and KD.
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spelling pubmed-73402442020-07-14 Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection Rigante, Donato Mediterr J Hematol Infect Dis Review Article Although the etiology of Kawasaki disease (KD) remains elusive, the available evidence indicates that the primum movens may be a dysregulated immune response to various microbial agents, leading to cytokine cascade and endothelial cell activation in patients with KD. Documented infections by different viruses in many individual cases have been largely reported and are discussed herein, but attempts to demonstrate their causative role in the distinctive KD scenario and KD epidemiological features have been disappointing. To date, no definite link has been irrefutably found between a single infection and KD. Università Cattolica del Sacro Cuore 2020-07-01 /pmc/articles/PMC7340244/ /pubmed/32670517 http://dx.doi.org/10.4084/MJHID.2020.039 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rigante, Donato
Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection
title Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection
title_full Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection
title_fullStr Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection
title_full_unstemmed Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection
title_short Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection
title_sort kawasaki disease as the immune-mediated echo of a viral infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340244/
https://www.ncbi.nlm.nih.gov/pubmed/32670517
http://dx.doi.org/10.4084/MJHID.2020.039
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