Cargando…

Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism

DHTKD1 is a lesser-studied E1 enzyme among the family of 2-oxoacid dehydrogenases. In complex with E2 (dihydrolipoamide succinyltransferase, DLST) and E3 (dihydrolipoamide dehydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan catabolism by catalysing the oxidative decarb...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bezerra, Gustavo A., Foster, William R., Bailey, Henry J., Hicks, Kevin G., Sauer, Sven W., Dimitrov, Bianca, McCorvie, Thomas J., Okun, Jürgen G., Rutter, Jared, Kölker, Stefan, Yue, Wyatt W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2020
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340257/ https://www.ncbi.nlm.nih.gov/pubmed/32695416 http://dx.doi.org/10.1107/S205225252000696X

Ejemplares similares

Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex
por: Cui, Zhicheng, et al.
Publicado: (2023)

Unique organization of photosystem II supercomplexes and megacomplexes in Norway spruce
por: Kouřil, Roman, et al.
Publicado: (2020)

Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae
por: Han, Fangzhu, et al.
Publicado: (2023)

Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain
por: Patel, Dipali, et al.
Publicado: (2016)

Photosystem I-LHCII megacomplexes respond to high light and aging in plants
por: Schwarz, Eliezer M., et al.
Publicado: (2017)

Heterozygous DHTKD1 Variants in Two European Cohorts of Amyotrophic Lateral Sclerosis Patients
por: Osmanovic, Alma, et al.
Publicado: (2021)

An evolving view of complex II—noncanonical complexes, megacomplexes, respiration, signaling, and beyond
por: Iverson, T.M., et al.
Publicado: (2023)

circDHTKD1 promotes lymphatic metastasis of bladder cancer by upregulating CXCL5
por: Lu, Qun, et al.
Publicado: (2022)

Signaling at the endosome: cryo‐EM structure of a GPCR–G protein–beta‐arrestin megacomplex
por: Nguyen, Anthony H., et al.
Publicado: (2021)

Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase
por: McCorvie, Thomas J., et al.
Publicado: (2016)

Structural basis of homologous recombination
por: Sun, Yueru, et al.
Publicado: (2019)

Galactosemia: Towards Pharmacological Chaperones
por: Banford, Samantha, et al.
Publicado: (2021)

COVID-19 Testing Strategies for K-12 Schools in California: A Cost-Effectiveness Analysis
por: Maya, Sigal, et al.
Publicado: (2022)

Assessing the accuracy of California county level COVID-19 hospitalization forecasts to inform public policy decision making
por: White, Lauren A., et al.
Publicado: (2023)

Knock-Out of DHTKD1 Alters Mitochondrial Respiration and Function, and May Represent a Novel Pathway in Cardiometabolic Disease Risk
por: Wang, Chuan, et al.
Publicado: (2021)

Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate
por: McCorvie, Thomas J., et al.
Publicado: (2022)

An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism
por: Thompson, Mitchell G., et al.
Publicado: (2020)

Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci
por: Sudarshan, Deepthi, et al.
Publicado: (2022)

The fate of lysine: Non-targeted stable isotope analysis reveals parallel ways for lysine catabolization in Phaeobacter inhibens
por: Reimer, Lorenz C., et al.
Publicado: (2017)

In vivo and in vitro function of human UDP-galactose 4′-epimerase variants
por: McCorvie, Thomas J., et al.
Publicado: (2011)

CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner
por: Sabbir, Mohammad Golam, et al.
Publicado: (2021)

Structural Insights into the MMACHC-MMADHC Protein Complex Involved in Vitamin B(12) Trafficking
por: Froese, D. Sean, et al.
Publicado: (2015)

CMT2Q-causing mutation in the Dhtkd1 gene lead to sensory defects, mitochondrial accumulation and altered metabolism in a knock-in mouse model
por: Luan, Chun-jie, et al.
Publicado: (2020)

Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production
por: Li, Wenna, et al.
Publicado: (2019)

QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis
por: Breuer, Maximilian, et al.
Publicado: (2019)

Circular RNA DHTKD1 targets miR‑338‑3p/ETS1 axis to regulate the inflammatory response in human bronchial epithelial cells
por: Qian, Fenhong, et al.
Publicado: (2023)

Inter-domain Communication of Human Cystathionine β-Synthase: STRUCTURAL BASIS OF S-ADENOSYL-l-METHIONINE ACTIVATION
por: McCorvie, Thomas J., et al.
Publicado: (2014)

The Molecular Dynamics of Trypanosoma brucei UDP-Galactose 4′-Epimerase: A Drug Target for African Sleeping Sickness
por: Friedman, Aaron J, et al.
Publicado: (2012)

Maleic Acid – but Not Structurally Related Methylmalonic Acid – Interrupts Energy Metabolism by Impaired Calcium Homeostasis
por: Tuncel, Ali Tunç, et al.
Publicado: (2015)

Oncogenic circDHTKD1 promotes tumor growth and metastasis of oral squamous cell carcinoma in vitro and in vivo via upregulating miR-326-mediated GAB1
por: Wu, Zhuangzhi, et al.
Publicado: (2021)

Lysine Catabolism Through the Saccharopine Pathway: Enzymes and Intermediates Involved in Plant Responses to Abiotic and Biotic Stress
por: Arruda, Paulo, et al.
Publicado: (2020)

Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment
por: Gül, Désirée, et al.
Publicado: (2023)

Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design
por: Froese, D. Sean, et al.
Publicado: (2015)

Glucose and fatty acids catabolism during in vitro decidualization of human endometrial stromal cells
por: Citrinovitz, Ana Cecilia Mestre, et al.
Publicado: (2022)

α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
por: Hu, Yuanyuan, et al.
Publicado: (2020)

Co‐catabolism of arginine and succinate drives symbiotic nitrogen fixation
por: Flores‐Tinoco, Carlos Eduardo, et al.
Publicado: (2020)

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain
por: Bezerra, Gustavo A., et al.
Publicado: (2021)

Regulatory mechanisms underlying coordination of amino acid and glucose catabolism in Escherichia coli
por: Zampieri, Mattia, et al.
Publicado: (2019)

Defining NAD(P)(H) Catabolism
por: Dhuguru, Jyothi, et al.
Publicado: (2023)

Novel homozygous variants in PRORP expand the genotypic spectrum of combined oxidative phosphorylation deficiency 54
por: Smith, Thomas B., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_i43q8kgu5ril5bofa5e22cikb9