Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein

The multidrug transporter P-glycoprotein (Pgp)/ABCB1/MDR1 plays an important role in multidrug resistance (MDR) and detoxification owing to its ability to efflux an unusually large and chemically diverse set of substrates. Previous phenylalanine-to-alanine scanning mutagenesis of Pgp revealed that n...

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Detalles Bibliográficos
Autores principales: Le, Christina A., Harvey, Daniel S., Aller, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340268/
https://www.ncbi.nlm.nih.gov/pubmed/32695413
http://dx.doi.org/10.1107/S2052252520005709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340268/
https://www.ncbi.nlm.nih.gov/pubmed/32695413
http://dx.doi.org/10.1107/S2052252520005709

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