Cargando…
Pneumothorax in connective tissue disease-associated interstitial lung disease
BACKGROUND: Spontaneous pneumothorax is a complication that occurs in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD); however, few studies on the clinical implications of pneumothorax for patients with CTD-ILD have been performed. OBJECTIVES: This study aimed...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340294/ https://www.ncbi.nlm.nih.gov/pubmed/32634173 http://dx.doi.org/10.1371/journal.pone.0235624 |
_version_ | 1783555024537780224 |
---|---|
author | Nishimoto, Koji Fujisawa, Tomoyuki Yoshimura, Katsuhiro Enomoto, Yasunori Yasui, Hideki Hozumi, Hironao Karayama, Masato Suzuki, Yuzo Furuhashi, Kazuki Enomoto, Noriyuki Nakamura, Yutaro Inui, Naoki Sumikawa, Hiromitsu Johkoh, Takeshi Suda, Takafumi |
author_facet | Nishimoto, Koji Fujisawa, Tomoyuki Yoshimura, Katsuhiro Enomoto, Yasunori Yasui, Hideki Hozumi, Hironao Karayama, Masato Suzuki, Yuzo Furuhashi, Kazuki Enomoto, Noriyuki Nakamura, Yutaro Inui, Naoki Sumikawa, Hiromitsu Johkoh, Takeshi Suda, Takafumi |
author_sort | Nishimoto, Koji |
collection | PubMed |
description | BACKGROUND: Spontaneous pneumothorax is a complication that occurs in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD); however, few studies on the clinical implications of pneumothorax for patients with CTD-ILD have been performed. OBJECTIVES: This study aimed to investigate the incidence and prognostic significance of pneumothorax and the risk factors for its onset in patients with CTD-ILD. METHODS: This study included 140 consecutive patients with CTD-ILD. Clinical characteristics, laboratory findings, pulmonary function test results, and chest high-resolution computed tomography (HRCT) images were retrospectively evaluated. RESULTS: A total of 18 patients (12.9%) developed pneumothorax during their clinical course. The cumulative incidence of pneumothorax from the time of CTD-ILD diagnosis was 6.5%, 8.7%, and 11.3% at 1, 3, and 5 years, respectively. The 10-year survival rate was significantly lower in patients with pneumothorax (29.6%) than that in those without pneumothorax (81.3%). The development of pneumothorax was significantly associated with poor prognosis (HR 22.0; p < 0.010). Furthermore, a lower body mass index, greater extent of reticular abnormalities on HRCT, and administration of methylprednisolone pulse therapy were significantly associated with the development of pneumothorax. CONCLUSION: Pneumothorax is a serious complication in the clinical course of patients with CTD-ILD and the onset of pneumothorax predicts a poor outcome. |
format | Online Article Text |
id | pubmed-7340294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-73402942020-07-17 Pneumothorax in connective tissue disease-associated interstitial lung disease Nishimoto, Koji Fujisawa, Tomoyuki Yoshimura, Katsuhiro Enomoto, Yasunori Yasui, Hideki Hozumi, Hironao Karayama, Masato Suzuki, Yuzo Furuhashi, Kazuki Enomoto, Noriyuki Nakamura, Yutaro Inui, Naoki Sumikawa, Hiromitsu Johkoh, Takeshi Suda, Takafumi PLoS One Research Article BACKGROUND: Spontaneous pneumothorax is a complication that occurs in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD); however, few studies on the clinical implications of pneumothorax for patients with CTD-ILD have been performed. OBJECTIVES: This study aimed to investigate the incidence and prognostic significance of pneumothorax and the risk factors for its onset in patients with CTD-ILD. METHODS: This study included 140 consecutive patients with CTD-ILD. Clinical characteristics, laboratory findings, pulmonary function test results, and chest high-resolution computed tomography (HRCT) images were retrospectively evaluated. RESULTS: A total of 18 patients (12.9%) developed pneumothorax during their clinical course. The cumulative incidence of pneumothorax from the time of CTD-ILD diagnosis was 6.5%, 8.7%, and 11.3% at 1, 3, and 5 years, respectively. The 10-year survival rate was significantly lower in patients with pneumothorax (29.6%) than that in those without pneumothorax (81.3%). The development of pneumothorax was significantly associated with poor prognosis (HR 22.0; p < 0.010). Furthermore, a lower body mass index, greater extent of reticular abnormalities on HRCT, and administration of methylprednisolone pulse therapy were significantly associated with the development of pneumothorax. CONCLUSION: Pneumothorax is a serious complication in the clinical course of patients with CTD-ILD and the onset of pneumothorax predicts a poor outcome. Public Library of Science 2020-07-07 /pmc/articles/PMC7340294/ /pubmed/32634173 http://dx.doi.org/10.1371/journal.pone.0235624 Text en © 2020 Nishimoto et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Nishimoto, Koji Fujisawa, Tomoyuki Yoshimura, Katsuhiro Enomoto, Yasunori Yasui, Hideki Hozumi, Hironao Karayama, Masato Suzuki, Yuzo Furuhashi, Kazuki Enomoto, Noriyuki Nakamura, Yutaro Inui, Naoki Sumikawa, Hiromitsu Johkoh, Takeshi Suda, Takafumi Pneumothorax in connective tissue disease-associated interstitial lung disease |
title | Pneumothorax in connective tissue disease-associated interstitial lung disease |
title_full | Pneumothorax in connective tissue disease-associated interstitial lung disease |
title_fullStr | Pneumothorax in connective tissue disease-associated interstitial lung disease |
title_full_unstemmed | Pneumothorax in connective tissue disease-associated interstitial lung disease |
title_short | Pneumothorax in connective tissue disease-associated interstitial lung disease |
title_sort | pneumothorax in connective tissue disease-associated interstitial lung disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340294/ https://www.ncbi.nlm.nih.gov/pubmed/32634173 http://dx.doi.org/10.1371/journal.pone.0235624 |
work_keys_str_mv | AT nishimotokoji pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT fujisawatomoyuki pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT yoshimurakatsuhiro pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT enomotoyasunori pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT yasuihideki pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT hozumihironao pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT karayamamasato pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT suzukiyuzo pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT furuhashikazuki pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT enomotonoriyuki pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT nakamurayutaro pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT inuinaoki pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT sumikawahiromitsu pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT johkohtakeshi pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease AT sudatakafumi pneumothoraxinconnectivetissuediseaseassociatedinterstitiallungdisease |