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The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae

The S. cerevisiae ISR1 gene encodes a putative kinase with no ascribed function. Here, we show that Isr1 acts as a negative regulator of the highly-conserved hexosamine biosynthesis pathway (HBP), which converts glucose into uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), the carbohydrate prec...

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Detalles Bibliográficos
Autores principales:	Alme, Emma B., Stevenson, Erica, Krogan, Nevan J., Swaney, Danielle L., Toczyski, David P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340321/ https://www.ncbi.nlm.nih.gov/pubmed/32579556 http://dx.doi.org/10.1371/journal.pgen.1008840

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