Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism

AIMS: Here, we aimed to determine the therapeutic effect of longevity-associated variant (LAV)-BPIFB4 gene therapy on atherosclerosis. METHODS AND RESULTS: ApoE knockout mice (ApoE(−/−)) fed a high-fat diet were randomly allocated to receive LAV-BPIFB4, wild-type (WT)-BPIFB4, or empty vector via ade...

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Detalles Bibliográficos
Autores principales: Puca, Annibale Alessandro, Carrizzo, Albino, Spinelli, Chiara, Damato, Antonio, Ambrosio, Mariateresa, Villa, Francesco, Ferrario, Anna, Maciag, Anna, Fornai, Francesco, Lenzi, Paola, Valenti, Valentina, di Nonno, Flavio, Accarino, Giulio, Madonna, Michele, Forte, Maurizio, Calì, Gaetano, Baragetti, Andrea, Norata, Giuseppe Danilo, Catapano, Alberico Luigi, Cattaneo, Monica, Izzo, Raffaele, Trimarco, Valentina, Montella, Francesco, Versaci, Francesco, Auricchio, Alberto, Frati, Giacomo, Sciarretta, Sebastiano, Madeddu, Paolo, Ciaglia, Elena, Vecchione, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340354/
https://www.ncbi.nlm.nih.gov/pubmed/31289820
http://dx.doi.org/10.1093/eurheartj/ehz459

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