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Osteoblast–Osteoclast Coculture Amplifies Inhibitory Effects of FG‐4592 on Human Osteoclastogenesis and Reduces Bone Resorption

The link between bone and blood vessels is regulated by hypoxia and the hypoxia‐inducible transcription factor, HIF, which drives both osteogenesis and angiogenesis. The recent clinical approval of PHD enzyme inhibitors, which stabilize HIF protein, introduces the potential for a new clinical strate...

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Detalles Bibliográficos
Autores principales:	Hulley, Philippa A, Papadimitriou‐Olivgeri, Ioanna, Knowles, Helen J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340438/ https://www.ncbi.nlm.nih.gov/pubmed/32666021 http://dx.doi.org/10.1002/jbm4.10370

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