Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor

BACKGROUND: α(2A)-adrenoceptor (AR) is a potential target for the treatment of degenerative diseases of the central nervous system, and α(2A)-AR agonists are effective drugs for this condition. However, the lack of high selectivity for α(2A)-AR subtype of traditional drugs greatly limits their clini...

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Detalles Bibliográficos
Autores principales: Li, Zaibing, Li, Jingyu, Liu, Liyan, Deng, Wenyi, Liu, Qingrong, Liu, Ruofan, Zhang, Wen, He, Zaiqing, Fan, Lei, Yang, Yingzhuo, Duan, Yun, Hou, Huifang, Wang, Xinyuan, Yang, Zhimei, Wang, Xiaoying, Chen, Shanze, Wang, Yi, Huang, Ning, Chen, Junli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340475/
https://www.ncbi.nlm.nih.gov/pubmed/32694911
http://dx.doi.org/10.2147/DDDT.S214157

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