Physiological and pathological insights into exosomes in the brain

Exosomes are small vesicles secreted by all cell types in the brain and play a role in cell-cell communication through the transfer of cargo or encapsulation. Exosomes in the brain have considerable impact on neuronal development, activation, and regeneration. In addition, exosomes are reported to b...

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Detalles Bibliográficos
Autores principales: Li, Xiao-Hui, Zhang, Juan, Li, Ding-Feng, Wu, Wei, Xie, Zhong-Wen, Liu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340524/
https://www.ncbi.nlm.nih.gov/pubmed/32400978
http://dx.doi.org/10.24272/j.issn.2095-8137.2020.043
Descripción
Sumario:Exosomes are small vesicles secreted by all cell types in the brain and play a role in cell-cell communication through the transfer of cargo or encapsulation. Exosomes in the brain have considerable impact on neuronal development, activation, and regeneration. In addition, exosomes are reported to be involved in the onset and propagation of various neurodegenerative diseases. In this review, we discuss the content of exosomes derived from major cell types in the brain, and their function under physiological and pathological conditions.

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