Cargando…

SOCS3 Attenuates GM-CSF/IFN-γ-Mediated Inflammation During Spontaneous Spinal Cord Regeneration

SOCS3, a feedback inhibitor of the JAK/STAT signal pathway, negatively regulates axonal regrowth and inflammation in the central nervous system (CNS). Here, we demonstrated a distinct role of SOCS3 in the injured spinal cord of the gecko following tail amputation. Severing the gecko spinal cord did...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xuejie, He, Bingqiang, Li, Hui, Wang, Yingjie, Zhou, Yue, Wang, Wenjuan, Song, Tiancheng, Du, Nan, Gu, Xingxing, Luo, Yi, Wang, Yongjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340708/ https://www.ncbi.nlm.nih.gov/pubmed/32306216 http://dx.doi.org/10.1007/s12264-020-00493-8

Ejemplares similares

SOCS-1 Mediates Ubiquitylation and Degradation of GM-CSF Receptor
por: Bunda, Severa, et al.
Publicado: (2013)

IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice
por: Hanada, Toshikatsu, et al.
Publicado: (2006)

IL-34 Induces the Differentiation of Human Monocytes into Immunosuppressive Macrophages. Antagonistic Effects of GM-CSF and IFNγ
por: Foucher, Etienne D., et al.
Publicado: (2013)

Correction: IL-34 Induces the Differentiation of Human Monocytes into Immunosuppressive Macrophages. Antagonistic Effects of GM-CSF and IFNγ
por: Foucher, Etienne D., et al.
Publicado: (2014)

Development of IFN-γ resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells
por: Fojtova, M, et al.
Publicado: (2007)

Cytokines, GM-CSF and IFNγ administered by priming and post-chemotherapy cycling in recurrent ovarian cancer patients receiving carboplatin
por: Apte, Sachin M, et al.
Publicado: (2006)

Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer
por: Enzler, Thomas, et al.
Publicado: (2003)

Cytokine/Chemokine Release Patterns and Transcriptomic Profiles of LPS/IFNγ-Activated Human Macrophages Differentiated with Heat-Killed Mycobacterium obuense, M-CSF, or GM-CSF
por: Bazzi, Samer, et al.
Publicado: (2021)

P1422: IN VIVO G-CSF TREATMENT ACTIVATES THE GR-SOCS1 AXIS TO SUPPRESS IFN-Γ SECRETION BY NATURAL KILLER CELLS
por: Cao, X., et al.
Publicado: (2022)

IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α
por: Van Dis, Erik, et al.
Publicado: (2022)

Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
por: Shen, Tingting, et al.
Publicado: (2017)

GM-CSF in inflammation
por: Hamilton, John A.
Publicado: (2019)

Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders
por: Lazarus, Hillard M., et al.
Publicado: (2023)

G-CSF and GM-CSF in clinical trials.
por: Antman, K. H.
Publicado: (1990)

Macrophage migration inhibitory factor facilitates production of CCL5 in astrocytes following rat spinal cord injury
por: Zhou, Yue, et al.
Publicado: (2018)

Differential Expression of IL-17, 22 and 23 in the Progression of Colorectal Cancer in Patients with K-ras Mutation: Ras Signal Inhibition and Crosstalk with GM-CSF and IFN-γ
por: Petanidis, Savvas, et al.
Publicado: (2013)

Elevated Levels of IFN-γ in CSF and Serum of Patients with Amyotrophic Lateral Sclerosis
por: Liu, Juan, et al.
Publicado: (2015)

A role for G-CSF and GM-CSF in nonmyeloid cancers
por: Aliper, Alexander M, et al.
Publicado: (2014)

GM-CSF-Dependent Inflammatory Pathways
por: Hamilton, John A.
Publicado: (2019)

Development of Dendritic Cells from GM-CSF(-/-) Mice in vitro : GM-CSF Enhances Production and Survival of Cells
por: Ni, Keping, et al.
Publicado: (2001)

Temozolomide followed by combined immunotherapy with GM-CSF, low-dose IL2 and IFNα in patients with metastatic melanoma
por: de Gast, G C, et al.
Publicado: (2003)

GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages
por: Cao, Weijie, et al.
Publicado: (2022)

Toll‐like receptor 4 regulates spontaneous intestinal tumorigenesis by up‐regulating IL‐6 and GM‐CSF
por: Shi, Yun‐Jie, et al.
Publicado: (2019)

Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF(+) T Lymphocytes
por: Bystrom, Jonas, et al.
Publicado: (2017)

Construction of Recombinant Human GM-CSF and GM-CSF-ApoA-I Fusion Protein and Evaluation of Their Biological Activity
por: Pykhtina, Mariya, et al.
Publicado: (2021)

Self-Control of Inflammation during Tail Regeneration of Lizards
por: He, Bingqiang, et al.
Publicado: (2021)

Association of Elevated Serum GM-CSF, IFN-γ, IL-4, and TNF-α Concentration with Tobacco Smoke Induced Chronic Obstructive Pulmonary Disease in a South Indian Population
por: Mitra, Ankita, et al.
Publicado: (2018)

Pivotal Roles of GM-CSF in Autoimmunity and Inflammation
por: Shiomi, Aoi, et al.
Publicado: (2015)

A Review of GM-CSF Therapy in Sepsis
por: Mathias, Brittany, et al.
Publicado: (2015)

The efficacy and safety of targeting GM-CSF in arthritis
por: Bykerk, Vivian P
Publicado: (2020)

GM-CSF: Orchestrating the Pulmonary Response to Infection
por: McCormick, Thomas S., et al.
Publicado: (2022)

Role of GM-CSF in lung balance and disease
por: Chen, Yingzi, et al.
Publicado: (2023)

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment
por: Bosteels, Cedric, et al.
Publicado: (2022)

Increased expression of IFN-γ in preeclampsia impairs human trophoblast invasion via a SOCS1/JAK/STAT1 feedback loop
por: Liu, Huiqiang, et al.
Publicado: (2021)

G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors
por: He, Kai, et al.
Publicado: (2022)

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
por: Wang, Xu, et al.
Publicado: (2023)

Glutamine Deprivation Promotes the Generation and Mobilization of MDSCs by Enhancing Expression of G-CSF and GM-CSF
por: Sun, Hong-Wei, et al.
Publicado: (2021)

Construction and in vitro evaluation of a recombinant live attenuated PRRSV expressing GM-CSF
por: Yu, Lingxue, et al.
Publicado: (2014)

Immunotherapy with concurrent subcutaneous GM-CSF, low-dose IL-2 and IFN-α in patients with progressive metastatic renal cell carcinoma
por: Verra, N, et al.
Publicado: (2003)

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies
por: Bonaventura, Aldo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mh3t6tgglk8vh4qa2ldpdr4cpg