Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling

BACKGROUND: Antioxidase alleviates the accumulation of radiation-induced reactive oxygen species (ROS) and therefore has strong connections with radioresistance. Isocitrate dehydrogenase 2 (IDH2) facilitates the turnover of antioxidase, but its role in radiotherapeutic efficiency in oesophageal squa...

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Detalles Bibliográficos
Autores principales: Chen, Xuan, Zhuo, Shichao, Xu, Wenzhe, Chen, Xue, Huang, Di, Sun, Xiaozheng, Cheng, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340793/
https://www.ncbi.nlm.nih.gov/pubmed/32367071
http://dx.doi.org/10.1038/s41416-020-0852-4

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