BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL‐induced DNA damage and endothelial apoptosis

Mutations in the tumor suppressor gene BRCA2 (BReast CAncer susceptibility gene 2) predispose carriers to breast, ovarian, and other cancers. In response to DNA damage, BRCA2 participates in homology‐directed DNA damage repair to maintain genome stability. Genome‐wide association studies have identi...

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Detalles Bibliográficos
Autores principales: Singh, Shweta, Nguyen, Hien, Michels, David, Bazinet, Hannah, Matkar, Pratiek N., Liu, Zongyi, Esene, Lilian, Adam, Mohamed, Bugyei‐Twum, Antoinette, Mebrahtu, Elizabeth, Joseph, Jameela, Ehsan, Mehroz, Chen, Hao H., Qadura, Mohammad, Singh, Krishna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340845/
https://www.ncbi.nlm.nih.gov/pubmed/32638521
http://dx.doi.org/10.14814/phy2.14481

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