Ventilation–perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O(2)

Proton magnetic resonance (MR) imaging to quantify regional ventilation–perfusion ( [Formula: see text]) ratios combines specific ventilation imaging (SVI) and separate proton density and perfusion measures into a composite map. Specific ventilation imaging exploits the paramagnetic properties of O(2), which alters the local MR signal intensity, in an F(I)O(2)‐dependent manner. Specific ventilation imaging data are acquired during five wash‐in/wash‐out cycles of breathing 21% O(2) alternating with 100% O(2) over ~20 min. This technique assumes that alternating F(I)O(2) does not affect [Formula: see text] heterogeneity, but this is unproven. We tested the hypothesis that alternating F(I)O(2) exposure increases [Formula: see text] mismatch in nine patients with abnormal pulmonary gas exchange and increased [Formula: see text] mismatch using the multiple inert gas elimination technique (MIGET).The following data were acquired (a) breathing air (baseline), (b) breathing alternating air/100% O(2) during an emulated‐SVI protocol (eSVI), and (c) 20 min after ambient air breathing (recovery). MIGET heterogeneity indices of shunt, deadspace, ventilation versus [Formula: see text] ratio, LogSD [Formula: see text] , and perfusion versus [Formula: see text] ratio, LogSD [Formula: see text] were calculated. LogSD [Formula: see text] was not different between eSVI and baseline (1.04 ± 0.39 baseline, 1.05 ± 0.38 eSVI, p = .84); but was reduced compared to baseline during recovery (0.97 ± 0.39, p = .04). There was no significant difference in LogSD [Formula: see text] across conditions (0.81 ± 0.30 baseline, 0.79 ± 0.15 eSVI, 0.79 ± 0.20 recovery; p = .54); Deadspace was not significantly different (p = .54) but shunt showed a borderline increase during eSVI (1.0% ± 1.0 baseline, 2.6% ± 2.9 eSVI; p = .052) likely from altered hypoxic pulmonary vasoconstriction and/or absorption atelectasis. Intermittent breathing of 100% O(2) does not substantially alter [Formula: see text] matching and if SVI measurements are made after perfusion measurements, any potential effects will be minimized.