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Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved

BACKGROUND AND AIM: Non-coding RNAs control cell functioning through affecting gene expression and translation and their dysregulation is associated with altered cell homeostasis and diseases, including cancer. Nutraceuticals with anti-cancer therapeutic potential have been shown to modulate non-cod...

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Autores principales: Vallino, Letizia, Ferraresi, Alessandra, Vidoni, Chiara, Secomandi, Eleonora, Esposito, Andrea, Dhanasekaran, Danny N., Isidoro, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340874/
https://www.ncbi.nlm.nih.gov/pubmed/32670816
http://dx.doi.org/10.1016/j.jtcme.2020.02.006
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author Vallino, Letizia
Ferraresi, Alessandra
Vidoni, Chiara
Secomandi, Eleonora
Esposito, Andrea
Dhanasekaran, Danny N.
Isidoro, Ciro
author_facet Vallino, Letizia
Ferraresi, Alessandra
Vidoni, Chiara
Secomandi, Eleonora
Esposito, Andrea
Dhanasekaran, Danny N.
Isidoro, Ciro
author_sort Vallino, Letizia
collection PubMed
description BACKGROUND AND AIM: Non-coding RNAs control cell functioning through affecting gene expression and translation and their dysregulation is associated with altered cell homeostasis and diseases, including cancer. Nutraceuticals with anti-cancer therapeutic potential have been shown to modulate non-coding RNAs expression that could impact on the expression of genes involved in the malignant phenotype. EXPERIMENTAL PROCEDURE: Here, we report on the microarray profiling of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) and on the associated biochemical pathways and functional processes potentially modulated in OVCAR-3 ovarian cancer cells exposed for 24 h to Resveratrol (RV), a nutraceutical that has been shown to inhibit carcinogenesis and cancer progression in a variety of human and animal models, both in vitro and in vivo. Diana tools and Gene Ontology (GO) pathway analyses along with Pubmed literature search were employed to identify the cellular processes possibly affected by the dysregulated miRNAs and lncRNAs. RESULTS AND CONCLUSION: The present data consistently support the contention that RV could exert anti-neoplastic activity via non-coding RNAs epigenetic modulation of the pathways governing cell homeostasis, cell proliferation, cell death and cell motility.
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spelling pubmed-73408742020-07-14 Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved Vallino, Letizia Ferraresi, Alessandra Vidoni, Chiara Secomandi, Eleonora Esposito, Andrea Dhanasekaran, Danny N. Isidoro, Ciro J Tradit Complement Med Ovarian cancer BACKGROUND AND AIM: Non-coding RNAs control cell functioning through affecting gene expression and translation and their dysregulation is associated with altered cell homeostasis and diseases, including cancer. Nutraceuticals with anti-cancer therapeutic potential have been shown to modulate non-coding RNAs expression that could impact on the expression of genes involved in the malignant phenotype. EXPERIMENTAL PROCEDURE: Here, we report on the microarray profiling of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) and on the associated biochemical pathways and functional processes potentially modulated in OVCAR-3 ovarian cancer cells exposed for 24 h to Resveratrol (RV), a nutraceutical that has been shown to inhibit carcinogenesis and cancer progression in a variety of human and animal models, both in vitro and in vivo. Diana tools and Gene Ontology (GO) pathway analyses along with Pubmed literature search were employed to identify the cellular processes possibly affected by the dysregulated miRNAs and lncRNAs. RESULTS AND CONCLUSION: The present data consistently support the contention that RV could exert anti-neoplastic activity via non-coding RNAs epigenetic modulation of the pathways governing cell homeostasis, cell proliferation, cell death and cell motility. Elsevier 2020-03-04 /pmc/articles/PMC7340874/ /pubmed/32670816 http://dx.doi.org/10.1016/j.jtcme.2020.02.006 Text en © 2020 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Ovarian cancer
Vallino, Letizia
Ferraresi, Alessandra
Vidoni, Chiara
Secomandi, Eleonora
Esposito, Andrea
Dhanasekaran, Danny N.
Isidoro, Ciro
Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved
title Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved
title_full Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved
title_fullStr Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved
title_full_unstemmed Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved
title_short Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved
title_sort modulation of non-coding rnas by resveratrol in ovarian cancer cells: in silico analysis and literature review of the anti-cancer pathways involved
topic Ovarian cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340874/
https://www.ncbi.nlm.nih.gov/pubmed/32670816
http://dx.doi.org/10.1016/j.jtcme.2020.02.006
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