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Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

RNA interference (RNAi) is a potent mechanism that silences mRNA and protein expression in all cells and tissue types. RNAi is known to exert many of its functional effects in the cytoplasm, and thus, the cellular localization of target mRNA may impact observed potency. Here, we demonstrate that cel...

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Detalles Bibliográficos
Autores principales:	Ferguson, Chantal M., Echeverria, Dimas, Hassler, Matthew, Ly, Socheata, Khvorova, Anastasia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340969/ https://www.ncbi.nlm.nih.gov/pubmed/32650236 http://dx.doi.org/10.1016/j.omtn.2020.06.006

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