Cargando…

Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

RNA interference (RNAi) is a potent mechanism that silences mRNA and protein expression in all cells and tissue types. RNAi is known to exert many of its functional effects in the cytoplasm, and thus, the cellular localization of target mRNA may impact observed potency. Here, we demonstrate that cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferguson, Chantal M., Echeverria, Dimas, Hassler, Matthew, Ly, Socheata, Khvorova, Anastasia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340969/ https://www.ncbi.nlm.nih.gov/pubmed/32650236 http://dx.doi.org/10.1016/j.omtn.2020.06.006

Ejemplares similares

Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy
por: Ly, Socheata, et al.
Publicado: (2020)

Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains
por: Ly, Socheata, et al.
Publicado: (2022)

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo
por: Biscans, Annabelle, et al.
Publicado: (2019)

2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA
por: Davis, Sarah M., et al.
Publicado: (2020)

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain
por: Alterman, Julia F, et al.
Publicado: (2015)

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease
por: O’Reilly, Daniel, et al.
Publicado: (2023)

Silencing E1A mRNA by RNA interference inhibits adenovirus replication
por: Chung, Y.-S., et al.
Publicado: (2007)

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
por: Osborn, Maire F, et al.
Publicado: (2019)

Visualization of self-delivering hydrophobically modified siRNA cellular internalization
por: Ly, Socheata, et al.
Publicado: (2017)

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1
por: Davis, Sarah M., et al.
Publicado: (2022)

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain
por: Nikan, Mehran, et al.
Publicado: (2016)

Target selectivity in mRNA silencing
por: Aronin, N
Publicado: (2006)

Silencing viruses by RNA interference
por: Colbère-Garapin, Florence, et al.
Publicado: (2005)

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity
por: Yamada, Ken, et al.
Publicado: (2021)

Gene silencing by RNA interference : technology and application /
Publicado: (2005)

Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries
por: Toro-Ascuy, Daniela, et al.
Publicado: (2016)

Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome
por: Batool, Zahra, et al.
Publicado: (2020)

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models
por: Conroy, Faith, et al.
Publicado: (2022)

Silencing genes in the kidney: antisense or RNA interference?
por: Wang, Jia-Hui, et al.
Publicado: (2008)

RNA editing of microRNA prevents RNA-induced silencing complex recognition of target mRNA
por: Cui, Yalei, et al.
Publicado: (2015)

Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex
por: Zhu, Lizhe, et al.
Publicado: (2021)

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA
por: Rothé, Benjamin, et al.
Publicado: (2015)

RNAi revised - target mRNA-dependent enhancement of gene silencing
por: Dornseifer, Simon, et al.
Publicado: (2015)

Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing
por: Salton, Maayan, et al.
Publicado: (2015)

Effect of Nanoparticle Conjugation on Gene Silencing by RNA Interference
por: Singh, Neetu, et al.
Publicado: (2010)

Disease-Causing Allele-Specific Silencing by RNA Interference
por: Hohjoh, Hirohiko
Publicado: (2013)

The Mechanism of RNA Interference and the Transposon Silencing in Caenorhabditis elegans
por: Tijsterman, Marcel, et al.
Publicado: (2002)

A Non-canonical RNA Silencing Pathway Promotes mRNA Degradation in Basal Fungi
por: Trieu, Trung Anh, et al.
Publicado: (2015)

RNA interference inhibits hepatitis E virus mRNA accumulation and protein synthesis in vitro
por: Huang, Fen, et al.
Publicado: (2010)

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing
por: Mir, Aamir, et al.
Publicado: (2018)

RNA stem structure governs coupling of dicing and gene silencing in RNA interference
por: Koh, Hye Ran, et al.
Publicado: (2017)

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs
por: Godinho, Bruno M.D.C., et al.
Publicado: (2022)

mRNA, a Revolution in Biomedicine
por: Baptista, Bruno, et al.
Publicado: (2021)

Silencing efficacy prediction: a retrospective study on target mRNA features
por: Pascut, Devis, et al.
Publicado: (2015)

Novel mRNA-silencing bodies at the synapse: A never-ending story
por: Thomas, María Gabriela, et al.
Publicado: (2016)

Accessibility and conservation: General features of bacterial small RNA–mRNA interactions?
por: Richter, Andreas S., et al.
Publicado: (2012)

CAPN5 gene silencing by short hairpin RNA interference
por: Nelson, Nnamdi G, et al.
Publicado: (2014)

Satellite RNAs interfere with the function of viral RNA silencing suppressors
por: Shen, Wan-Xia, et al.
Publicado: (2015)

Gene silencing by RNA interference in the ectoparasitic mite, Psoroptes ovis
por: Marr, Edward J., et al.
Publicado: (2018)

RNA interference: From gene silencing to gene-specific therapeutics
por: Leung, Ray K.M., et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_0tdd01i7h8j79ecu227l95cglh