Treatment of invasive Paget’s disease of the vulva in pregnancy: A case report

• Invasive adenocarcinoma of the vulva arising from extramammary Paget’s disease is possible in women of child-bearing age. • Radical vulvectomy, sentinel lymph node biopsy, and inguinal lymphadenectomy are safe and feasible during pregnancy. • Chemotherapy may be used as adjuvant therapy for vulvar adenocarcinoma during pregnancy when radiation is contraindicated. • Primary cesarean delivery may be considered for pregnant women with recent vulvar surgery. • Trastuzumab may be considered for maintenance therapy of Her2/Neu positive vulvar cancer in postpartum women.