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Predictive value of pregnancy-associated plasma protein-A in relation to fetal loss: A systematic review and meta-analysis

BACKGROUND: For a woman with bleeding and threatened abortion, ultrasound scan is done to confirm the viability of the fetus; however, 10-15% of the embryos are eventually aborted. Distinguishing between women with good and poor prognosis can be a helpful approach. OBJECTIVE: This study aimed to rev...

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Autores principales: Hadizadeh-Talasaz, Zahra, Taghipour, Ali, Mousavi-Vahed, Seyede Houra, Roudsari, Robab Latifnejad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Knowledge E 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340989/
https://www.ncbi.nlm.nih.gov/pubmed/32754675
http://dx.doi.org/10.18502/ijrm.v13i6.7281
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author Hadizadeh-Talasaz, Zahra
Taghipour, Ali
Mousavi-Vahed, Seyede Houra
Roudsari, Robab Latifnejad
author_facet Hadizadeh-Talasaz, Zahra
Taghipour, Ali
Mousavi-Vahed, Seyede Houra
Roudsari, Robab Latifnejad
author_sort Hadizadeh-Talasaz, Zahra
collection PubMed
description BACKGROUND: For a woman with bleeding and threatened abortion, ultrasound scan is done to confirm the viability of the fetus; however, 10-15% of the embryos are eventually aborted. Distinguishing between women with good and poor prognosis can be a helpful approach. OBJECTIVE: This study aimed to review the predictive value of Pregnancy-associated Plasma Protein A (PAPP-A) in relation to the diagnosis of fetal loss. MATERIALS AND METHODS: The articles published in multiple databases including Web of Science, PubMed, MEDLINE, Scopus, and Persian databases such as ISC, Magiran, and IranMedx were searched for articles published until May 2019. MeSH terms was used for searching the databases including fetal loss OR pregnancy loss OR abortion OR miscarriage with the following word using AND; Pregnancy-Associated Plasma Protein-A OR PAPP-A. Two reviewers extracted data and recorded them in a pre-defined form and assessed the quality of articles using the Newcastle-Ottawa tool. Meta-analysis was done using the Comprehensive Meta-Analysis/2.0 software and MetaDisc. RESULTS: A total number of 16 studies were eligible for the qualitative data synthesis, out of which 8 studies were included in the meta-analysis. All studies had high and medium quality. The forest plot analysis showed a sensitivity of 57% (95% CI: 53-63%), a specificity of 83% (95% CI: 80-85%), a positive likelihood ratio of 3.52 (95% CI: 2.44-5.07), a negative likelihood ratio of 0.54 (95% CI: 0.37-0.79), and a diagnostic odds ratio of 6.95 (95% CI: 3.58-13.50). CONCLUSION: PAPP-A cannot be recommended on a routine basis for predicting fetal loss and still further research with a combination of other biomarkers is required.
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spelling pubmed-73409892020-08-03 Predictive value of pregnancy-associated plasma protein-A in relation to fetal loss: A systematic review and meta-analysis Hadizadeh-Talasaz, Zahra Taghipour, Ali Mousavi-Vahed, Seyede Houra Roudsari, Robab Latifnejad Int J Reprod Biomed Review Article BACKGROUND: For a woman with bleeding and threatened abortion, ultrasound scan is done to confirm the viability of the fetus; however, 10-15% of the embryos are eventually aborted. Distinguishing between women with good and poor prognosis can be a helpful approach. OBJECTIVE: This study aimed to review the predictive value of Pregnancy-associated Plasma Protein A (PAPP-A) in relation to the diagnosis of fetal loss. MATERIALS AND METHODS: The articles published in multiple databases including Web of Science, PubMed, MEDLINE, Scopus, and Persian databases such as ISC, Magiran, and IranMedx were searched for articles published until May 2019. MeSH terms was used for searching the databases including fetal loss OR pregnancy loss OR abortion OR miscarriage with the following word using AND; Pregnancy-Associated Plasma Protein-A OR PAPP-A. Two reviewers extracted data and recorded them in a pre-defined form and assessed the quality of articles using the Newcastle-Ottawa tool. Meta-analysis was done using the Comprehensive Meta-Analysis/2.0 software and MetaDisc. RESULTS: A total number of 16 studies were eligible for the qualitative data synthesis, out of which 8 studies were included in the meta-analysis. All studies had high and medium quality. The forest plot analysis showed a sensitivity of 57% (95% CI: 53-63%), a specificity of 83% (95% CI: 80-85%), a positive likelihood ratio of 3.52 (95% CI: 2.44-5.07), a negative likelihood ratio of 0.54 (95% CI: 0.37-0.79), and a diagnostic odds ratio of 6.95 (95% CI: 3.58-13.50). CONCLUSION: PAPP-A cannot be recommended on a routine basis for predicting fetal loss and still further research with a combination of other biomarkers is required. Knowledge E 2020-06-30 /pmc/articles/PMC7340989/ /pubmed/32754675 http://dx.doi.org/10.18502/ijrm.v13i6.7281 Text en Copyright © 2020 Hadizadeh-Talasaz et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review Article
Hadizadeh-Talasaz, Zahra
Taghipour, Ali
Mousavi-Vahed, Seyede Houra
Roudsari, Robab Latifnejad
Predictive value of pregnancy-associated plasma protein-A in relation to fetal loss: A systematic review and meta-analysis
title Predictive value of pregnancy-associated plasma protein-A in relation to fetal loss: A systematic review and meta-analysis
title_full Predictive value of pregnancy-associated plasma protein-A in relation to fetal loss: A systematic review and meta-analysis
title_fullStr Predictive value of pregnancy-associated plasma protein-A in relation to fetal loss: A systematic review and meta-analysis
title_full_unstemmed Predictive value of pregnancy-associated plasma protein-A in relation to fetal loss: A systematic review and meta-analysis
title_short Predictive value of pregnancy-associated plasma protein-A in relation to fetal loss: A systematic review and meta-analysis
title_sort predictive value of pregnancy-associated plasma protein-a in relation to fetal loss: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340989/
https://www.ncbi.nlm.nih.gov/pubmed/32754675
http://dx.doi.org/10.18502/ijrm.v13i6.7281
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