Cargando…

Trajectory and Functional Analysis of PD‐1(high) CD4(+)CD8(+) T Cells in Hepatocellular Carcinoma by Single‐Cell Cytometry and Transcriptome Sequencing

The spatial heterogeneity of immune microenvironment in hepatocellular carcinoma (HCC) remains elusive. Here, a single‐cell study involving 17 432 600 immune cells of 39 matched HCC (T), nontumor (N), and leading‐edge (L) specimens by mass cytometry is conducted. The tumor‐associated CD4/CD8 double‐...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Bo, Wang, Dongfang, Qiu, Xinyao, Luo, Guijuan, Wu, Tong, Yang, Shuai, Li, Zhixuan, Zhu, Yanjing, Wang, Shan, Wu, Rui, Sui, Chengjun, Gu, Ziqi, Shen, Siyun, Jeong, Seogsong, Wu, Xuan, Gu, Jin, Wang, Hongyang, Chen, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341083/ https://www.ncbi.nlm.nih.gov/pubmed/32670760 http://dx.doi.org/10.1002/advs.202000224

Ejemplares similares

The identification and functional analysis of CD8+PD-1+CD161+ T cells in hepatocellular carcinoma
por: Li, Zhixuan, et al.
Publicado: (2020)

Comprehensive analysis of spatial architecture in primary liver cancer
por: Wu, Rui, et al.
Publicado: (2021)

Integrative molecular analysis of metastatic hepatocellular carcinoma
por: Wang, Dongfang, et al.
Publicado: (2019)

Variable density of CD8+ and CD25+ programmed cell death-1 (PD-1) ligand (PD-L1) CD4+ T cells within the tumor microenvironment causes differential responses to the PD-1/PD-L1 blockade
por: Wu, Si-Pei, et al.
Publicado: (2015)

Uncovering PD-L1 and CD8(+) TILS Expression and Clinical Implication in Cervical Squamous Cell Carcinoma
por: Chen, Jingjing, et al.
Publicado: (2020)

Latent Risk Intrahepatic Cholangiocarcinoma Susceptible to Adjuvant Treatment After Resection: A Clinical Deep Learning Approach
por: Jeong, Seogsong, et al.
Publicado: (2020)

Single-cell atlas of diverse immune populations in the advanced biliary tract cancer microenvironment
por: Shi, Xuebing, et al.
Publicado: (2022)

Sensitivity and Specificity of CD19.CAR-T Cell Detection by Flow Cytometry and PCR
por: Schanda, Nicola, et al.
Publicado: (2021)

BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer
por: Feng, Mei, et al.
Publicado: (2021)

Three-color flow cytometry detection of virus-specific CD4+ and CD8+ T cells in the cat
por: de Groot-Mijnes, Jolanda D.F., et al.
Publicado: (2004)

Circulating memory PD-1(+)CD8(+) T cells and PD-1(+)CD8(+)T/PD-1(+)CD4(+)T cell ratio predict response and outcome to immunotherapy in advanced gastric cancer patients
por: Liu, Jiang, et al.
Publicado: (2023)

Safety and efficacy of co-administration of CD19 and CD22 CAR-T cells in children with B-ALL relapse after CD19 CAR-T therapy
por: Li, Wenjie, et al.
Publicado: (2023)

Clinical significance of CD38 and CD101 expression in PD-1(+)CD8(+) T cells in patients with epithelial ovarian cancer
por: Zhou, Jian, et al.
Publicado: (2020)

Hepatobiliary Tumor Organoids Reveal HLA Class I Neoantigen Landscape and Antitumoral Activity of Neoantigen Peptide Enhanced with Immune Checkpoint Inhibitors
por: Wang, Wenwen, et al.
Publicado: (2022)

Single-cell analysis by mass cytometry reveals CD19 CAR T cell spatiotemporal plasticity in patients
por: Goldberg, Lior, et al.
Publicado: (2022)

Heterogeneity and Differentiation Trajectories of Infiltrating CD8+ T Cells in Lung Adenocarcinoma
por: Song, Xiaojie, et al.
Publicado: (2022)

Change in PD-L1 and CD8 Expression after Chemoradiotherapy for Esophageal Squamous Cell Carcinoma
por: Chen, Wei-Chung, et al.
Publicado: (2022)

Comparative expression analysis of PD-1, PD-L1, and CD8A in lung adenocarcinoma
por: Ma, Ke, et al.
Publicado: (2020)

PD-1 blocking strategy for enhancing the anti-tumor effect of CAR T cells targeted CD105
por: Wang, Xi, et al.
Publicado: (2023)

Flow Cytometry Assessment of In Vitro Generated CD138(+) Human Plasma Cells
por: Itoua Maïga, Rayelle, et al.
Publicado: (2014)

Mass Cytometry Defines Virus-Specific CD4(+) T Cells in Influenza Vaccination
por: Subrahmanyam, Priyanka B., et al.
Publicado: (2020)

Quantifying CD4 receptor protein in two human CD4+ lymphocyte preparations for quantitative flow cytometry
por: Wang, Meiyao, et al.
Publicado: (2014)

NKT Cells in Mice Originate from Cytoplasmic CD3-Positive, CD4(−)CD8(−) Double-Negative Thymocytes that Express CD44 and IL-7Rα
por: Hu, Zhansheng, et al.
Publicado: (2019)

Comparison of Volumetric and Bead‐Based Counting of CD34 Cells by Single‐Platform Flow Cytometry
por: Saraiva, Luisa, et al.
Publicado: (2019)

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade
por: Banchereau, Romain, et al.
Publicado: (2021)

CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1(+) viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion
por: Correa-Rocha, Rafael, et al.
Publicado: (2018)

Immunohistochemical Expression and Prognostic Value of CD97 and Its Ligand CD55 in Primary Gallbladder Carcinoma
por: Wu, Jinsheng, et al.
Publicado: (2012)

CD80 Expressed by CD8(+) T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8(+) T Cells
por: Rollins, Meagan R., et al.
Publicado: (2017)

PD-1 and BTLA and CD8(+) T-cell “exhaustion” in cancer: “Exercising” an alternative viewpoint
por: Haymaker, Cara, et al.
Publicado: (2012)

Decreased blood CD4+PD-1+ and CD8+PD-1+ T cells in psoriatic patients with and without arthritis
por: Bartosińska, Joanna, et al.
Publicado: (2018)

Characterisation of an epigenetically altered CD4(+) CD28(+) Kir(+) T cell subset in autoimmune rheumatic diseases by multiparameter flow cytometry
por: Strickland, Faith M, et al.
Publicado: (2016)

Direct Detection of FoxP3 Expression in Thymic Double-Negative CD4(−)CD8(−) Cells by Flow Cytometry
por: Liu, Gang, et al.
Publicado: (2014)

Identification and Functional Analysis of Human CD56(neg) NK Cells by Flow Cytometry
por: Orrantia, Ane, et al.
Publicado: (2020)

Decreased CD8(+)CD28(+)/CD8(+)CD28(–) T cell ratio can sensitively predict poor outcome for patients with complicated Crohn disease
por: Dai, Shi-xue, et al.
Publicado: (2017)

CD38 identifies pre-activated CD8+ T cells which can be reinvigorated by anti-PD-1 blockade in human lung cancer
por: Wu, Pin, et al.
Publicado: (2021)

The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy
por: Jiang, Xuan, et al.
Publicado: (2023)

PD-1(+)CD8(+) T Cells Proximal to PD-L1(+)CD68(+) Macrophages Are Associated with Poor Prognosis in Pancreatic Ductal Adenocarcinoma Patients
por: Yang, Xiaobao, et al.
Publicado: (2023)

Hollow Spherical Pd/CdS/NiS with Carrier Spatial Separation for Photocatalytic Hydrogen Generation
por: Wang, Xiao, et al.
Publicado: (2023)

Gliomasphere marker combinatorics: multidimensional flow cytometry detects CD44+/CD133+/ITGA6+/CD36+ signature
por: Erhart, Friedrich, et al.
Publicado: (2018)

Staphylococcus aureus convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) T cells via the PD-1/PD-L1 axis
por: Rabe, Hardis, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qqfglj1s308b48a3336s3lsi8c