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Whole-Genome Comparative and Pathogenicity Analysis of Salmonella enterica subsp. enterica Serovar Rissen
Salmonella are a type of bacteria known to cause food-borne illness. Their host range varies widely, and their susceptibility to the host determines its pathogenicity. Salmonella enterica serovar Rissen (S. Rissen) is a widely distributed serotype; however, its virulence and pathogenicity are poorly...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Genetics Society of America
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341144/ https://www.ncbi.nlm.nih.gov/pubmed/32358017 http://dx.doi.org/10.1534/g3.120.401201 |
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author | Zhou, Aiping Li, Jun Xu, Zhihong Ni, Jinjing Guo, Jian Yao, Yu-Feng Wu, Wenjuan |
author_facet | Zhou, Aiping Li, Jun Xu, Zhihong Ni, Jinjing Guo, Jian Yao, Yu-Feng Wu, Wenjuan |
author_sort | Zhou, Aiping |
collection | PubMed |
description | Salmonella are a type of bacteria known to cause food-borne illness. Their host range varies widely, and their susceptibility to the host determines its pathogenicity. Salmonella enterica serovar Rissen (S. Rissen) is a widely distributed serotype; however, its virulence and pathogenicity are poorly understood. In this study, the pathogenicity and antibiotic resistance of a representative S. Rissen isolate were investigated. The cell model results showed that S. Rissen preferred to replicate in human macrophage cells U937 compared to murine macrophage cells RAW264.7, suggesting that it has a level of host adaptability. Genome sequencing and comparison analysis revealed that the distribution and nonsynonymous single nucleotide polymorphisms of virulence factors in S. Rissen were similar to those in S. Typhi rather than to those in S. Typhimurium. Taken together, our results suggest that although S. Rissen is a common serotype distributed in swine herds, pork and chicken products, it has strong ability to infect humans. |
format | Online Article Text |
id | pubmed-7341144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Genetics Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-73411442020-07-21 Whole-Genome Comparative and Pathogenicity Analysis of Salmonella enterica subsp. enterica Serovar Rissen Zhou, Aiping Li, Jun Xu, Zhihong Ni, Jinjing Guo, Jian Yao, Yu-Feng Wu, Wenjuan G3 (Bethesda) Genome Report Salmonella are a type of bacteria known to cause food-borne illness. Their host range varies widely, and their susceptibility to the host determines its pathogenicity. Salmonella enterica serovar Rissen (S. Rissen) is a widely distributed serotype; however, its virulence and pathogenicity are poorly understood. In this study, the pathogenicity and antibiotic resistance of a representative S. Rissen isolate were investigated. The cell model results showed that S. Rissen preferred to replicate in human macrophage cells U937 compared to murine macrophage cells RAW264.7, suggesting that it has a level of host adaptability. Genome sequencing and comparison analysis revealed that the distribution and nonsynonymous single nucleotide polymorphisms of virulence factors in S. Rissen were similar to those in S. Typhi rather than to those in S. Typhimurium. Taken together, our results suggest that although S. Rissen is a common serotype distributed in swine herds, pork and chicken products, it has strong ability to infect humans. Genetics Society of America 2020-05-01 /pmc/articles/PMC7341144/ /pubmed/32358017 http://dx.doi.org/10.1534/g3.120.401201 Text en Copyright © 2020 Zhou et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Genome Report Zhou, Aiping Li, Jun Xu, Zhihong Ni, Jinjing Guo, Jian Yao, Yu-Feng Wu, Wenjuan Whole-Genome Comparative and Pathogenicity Analysis of Salmonella enterica subsp. enterica Serovar Rissen |
title | Whole-Genome Comparative and Pathogenicity Analysis of Salmonella enterica subsp. enterica Serovar Rissen |
title_full | Whole-Genome Comparative and Pathogenicity Analysis of Salmonella enterica subsp. enterica Serovar Rissen |
title_fullStr | Whole-Genome Comparative and Pathogenicity Analysis of Salmonella enterica subsp. enterica Serovar Rissen |
title_full_unstemmed | Whole-Genome Comparative and Pathogenicity Analysis of Salmonella enterica subsp. enterica Serovar Rissen |
title_short | Whole-Genome Comparative and Pathogenicity Analysis of Salmonella enterica subsp. enterica Serovar Rissen |
title_sort | whole-genome comparative and pathogenicity analysis of salmonella enterica subsp. enterica serovar rissen |
topic | Genome Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341144/ https://www.ncbi.nlm.nih.gov/pubmed/32358017 http://dx.doi.org/10.1534/g3.120.401201 |
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