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Heritable arrhythmia syndromes associated with abnormal cardiac sodium channel function: ionic and non-ionic mechanisms

The cardiac sodium channel Na(V)1.5, encoded by the SCN5A gene, is responsible for the fast upstroke of the action potential. Mutations in SCN5A may cause sodium channel dysfunction by decreasing peak sodium current, which slows conduction and facilitates reentry-based arrhythmias, and by enhancing...

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Detalles Bibliográficos
Autores principales: Rivaud, Mathilde R, Delmar, Mario, Remme, Carol Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341171/
https://www.ncbi.nlm.nih.gov/pubmed/32251506
http://dx.doi.org/10.1093/cvr/cvaa082

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