Cargando…
Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial
OBJECTIVE: To explore whether Chuang Ling Ye (CLY), a traditional Chinese herbal medicine compound, could improve the treatment of idiopathic granulomatous mastitis (IGM) via decreasing inflammatory response. METHODS: Herein, 40 patients with IGM who had wounds requiring dressing change were enrolle...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341429/ https://www.ncbi.nlm.nih.gov/pubmed/32714413 http://dx.doi.org/10.1155/2020/6964801 |
_version_ | 1783555237888393216 |
---|---|
author | Xue, Jing-xian Ye, Bei Liu, Shun Cao, Si-han Bian, Wei-he Yao, Chang |
author_facet | Xue, Jing-xian Ye, Bei Liu, Shun Cao, Si-han Bian, Wei-he Yao, Chang |
author_sort | Xue, Jing-xian |
collection | PubMed |
description | OBJECTIVE: To explore whether Chuang Ling Ye (CLY), a traditional Chinese herbal medicine compound, could improve the treatment of idiopathic granulomatous mastitis (IGM) via decreasing inflammatory response. METHODS: Herein, 40 patients with IGM who had wounds requiring dressing change were enrolled and randomly divided into two groups: the CLY group and the control group. The size of the neoplasm and pain score of patients were followed-up for 4 weeks. Local tissues were taken during dressing change and examined by commercial enzyme-linked immunosorbent assay (ELISA) kits. The levels of inflammatory markers, including interleukin-1β (IL-1β), IL-2, IL-6, interferon gamma (IFN-γ), and tumor necrosis factor-α (TNF-α) were measured. RESULTS: After treatment, the size of the neoplasm in the CLY group was significantly smaller than that in the control group (14.28 cm ± 8.96 cm vs. 21.14 cm ± 0.12 cm, P=0.038), and the pain scores were markedly reduced (P=0.004). Besides, CLY downregulated the expression levels of IL-1β, IFN-γ, and TNF-α. CONCLUSION: External use of CLY could reduce the neoplasm of IGM by inhibiting local inflammation. This trial is registered with ChiCTR1800017744. |
format | Online Article Text |
id | pubmed-7341429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-73414292020-07-25 Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial Xue, Jing-xian Ye, Bei Liu, Shun Cao, Si-han Bian, Wei-he Yao, Chang Evid Based Complement Alternat Med Research Article OBJECTIVE: To explore whether Chuang Ling Ye (CLY), a traditional Chinese herbal medicine compound, could improve the treatment of idiopathic granulomatous mastitis (IGM) via decreasing inflammatory response. METHODS: Herein, 40 patients with IGM who had wounds requiring dressing change were enrolled and randomly divided into two groups: the CLY group and the control group. The size of the neoplasm and pain score of patients were followed-up for 4 weeks. Local tissues were taken during dressing change and examined by commercial enzyme-linked immunosorbent assay (ELISA) kits. The levels of inflammatory markers, including interleukin-1β (IL-1β), IL-2, IL-6, interferon gamma (IFN-γ), and tumor necrosis factor-α (TNF-α) were measured. RESULTS: After treatment, the size of the neoplasm in the CLY group was significantly smaller than that in the control group (14.28 cm ± 8.96 cm vs. 21.14 cm ± 0.12 cm, P=0.038), and the pain scores were markedly reduced (P=0.004). Besides, CLY downregulated the expression levels of IL-1β, IFN-γ, and TNF-α. CONCLUSION: External use of CLY could reduce the neoplasm of IGM by inhibiting local inflammation. This trial is registered with ChiCTR1800017744. Hindawi 2020-06-29 /pmc/articles/PMC7341429/ /pubmed/32714413 http://dx.doi.org/10.1155/2020/6964801 Text en Copyright © 2020 Jing-xian Xue et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Xue, Jing-xian Ye, Bei Liu, Shun Cao, Si-han Bian, Wei-he Yao, Chang Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial |
title | Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial |
title_full | Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial |
title_fullStr | Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial |
title_full_unstemmed | Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial |
title_short | Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial |
title_sort | treatment efficacy of chuang ling ye, a traditional chinese herbal medicine compound, on idiopathic granulomatous mastitis: a randomized controlled trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341429/ https://www.ncbi.nlm.nih.gov/pubmed/32714413 http://dx.doi.org/10.1155/2020/6964801 |
work_keys_str_mv | AT xuejingxian treatmentefficacyofchuanglingyeatraditionalchineseherbalmedicinecompoundonidiopathicgranulomatousmastitisarandomizedcontrolledtrial AT yebei treatmentefficacyofchuanglingyeatraditionalchineseherbalmedicinecompoundonidiopathicgranulomatousmastitisarandomizedcontrolledtrial AT liushun treatmentefficacyofchuanglingyeatraditionalchineseherbalmedicinecompoundonidiopathicgranulomatousmastitisarandomizedcontrolledtrial AT caosihan treatmentefficacyofchuanglingyeatraditionalchineseherbalmedicinecompoundonidiopathicgranulomatousmastitisarandomizedcontrolledtrial AT bianweihe treatmentefficacyofchuanglingyeatraditionalchineseherbalmedicinecompoundonidiopathicgranulomatousmastitisarandomizedcontrolledtrial AT yaochang treatmentefficacyofchuanglingyeatraditionalchineseherbalmedicinecompoundonidiopathicgranulomatousmastitisarandomizedcontrolledtrial |