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Prevalence of hepatitis C in the adult population of Bulgaria: a pilot study

OBJECTIVE: This study piloted a European technical protocol for conducting chronic hepatitis C prevalence surveys in the general population. The pilot study took place in the Bulgarian city of Stara Zagora in 2018, and results of setting up, conducting and evaluating the survey are presented. RESULT...

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Autores principales: Sperle, Ida, Nielsen, Stine, Gassowski, Martyna, Naneva, Zlatina, Perchemlieva, Tanya, Amato-Gauci, Andrew, an der Heiden, Matthias, Bremer, Viviane, Golkocheva-Markova, Elitsa, Hristov, Kristiyan, Kaneva, Elena, Simeonova, Yanita, Tenev, Tencho, Varleva, Tonka, Duffell, Erika, Zimmermann, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341663/
https://www.ncbi.nlm.nih.gov/pubmed/32635926
http://dx.doi.org/10.1186/s13104-020-05158-3
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author Sperle, Ida
Nielsen, Stine
Gassowski, Martyna
Naneva, Zlatina
Perchemlieva, Tanya
Amato-Gauci, Andrew
an der Heiden, Matthias
Bremer, Viviane
Golkocheva-Markova, Elitsa
Hristov, Kristiyan
Kaneva, Elena
Simeonova, Yanita
Tenev, Tencho
Varleva, Tonka
Duffell, Erika
Zimmermann, Ruth
author_facet Sperle, Ida
Nielsen, Stine
Gassowski, Martyna
Naneva, Zlatina
Perchemlieva, Tanya
Amato-Gauci, Andrew
an der Heiden, Matthias
Bremer, Viviane
Golkocheva-Markova, Elitsa
Hristov, Kristiyan
Kaneva, Elena
Simeonova, Yanita
Tenev, Tencho
Varleva, Tonka
Duffell, Erika
Zimmermann, Ruth
author_sort Sperle, Ida
collection PubMed
description OBJECTIVE: This study piloted a European technical protocol for conducting chronic hepatitis C prevalence surveys in the general population. The pilot study took place in the Bulgarian city of Stara Zagora in 2018, and results of setting up, conducting and evaluating the survey are presented. RESULTS: A probability-based sample of the general adult population was drawn from the local population registry, stratified by age and sex. A sample size of 999 was calculated, and accounting for 50% non-response, 1998 registered invitation letters were sent. Venous blood samples and questionnaire data were collected by the Regional Health Inspectorate in Stara Zagora. Blood samples were tested for anti-HCV, and if reactive for RNA. 252 (21.6%) of the participants were included in the study. Mean age and sex distribution differed between the participants (55.9 years, 60.3% females) and the total sample (48.9 years, 53.4%). The weighted chronic HCV prevalence among participants was 0.9% [95% CI 0.2–4.2%]. The approach of only sending registered letters contributed to a low response rate, and more efforts are needed to reduce non-response, especially among men and younger age groups. Results of the evaluation were integrated in the final technical protocol.
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spelling pubmed-73416632020-07-14 Prevalence of hepatitis C in the adult population of Bulgaria: a pilot study Sperle, Ida Nielsen, Stine Gassowski, Martyna Naneva, Zlatina Perchemlieva, Tanya Amato-Gauci, Andrew an der Heiden, Matthias Bremer, Viviane Golkocheva-Markova, Elitsa Hristov, Kristiyan Kaneva, Elena Simeonova, Yanita Tenev, Tencho Varleva, Tonka Duffell, Erika Zimmermann, Ruth BMC Res Notes Research Note OBJECTIVE: This study piloted a European technical protocol for conducting chronic hepatitis C prevalence surveys in the general population. The pilot study took place in the Bulgarian city of Stara Zagora in 2018, and results of setting up, conducting and evaluating the survey are presented. RESULTS: A probability-based sample of the general adult population was drawn from the local population registry, stratified by age and sex. A sample size of 999 was calculated, and accounting for 50% non-response, 1998 registered invitation letters were sent. Venous blood samples and questionnaire data were collected by the Regional Health Inspectorate in Stara Zagora. Blood samples were tested for anti-HCV, and if reactive for RNA. 252 (21.6%) of the participants were included in the study. Mean age and sex distribution differed between the participants (55.9 years, 60.3% females) and the total sample (48.9 years, 53.4%). The weighted chronic HCV prevalence among participants was 0.9% [95% CI 0.2–4.2%]. The approach of only sending registered letters contributed to a low response rate, and more efforts are needed to reduce non-response, especially among men and younger age groups. Results of the evaluation were integrated in the final technical protocol. BioMed Central 2020-07-07 /pmc/articles/PMC7341663/ /pubmed/32635926 http://dx.doi.org/10.1186/s13104-020-05158-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Sperle, Ida
Nielsen, Stine
Gassowski, Martyna
Naneva, Zlatina
Perchemlieva, Tanya
Amato-Gauci, Andrew
an der Heiden, Matthias
Bremer, Viviane
Golkocheva-Markova, Elitsa
Hristov, Kristiyan
Kaneva, Elena
Simeonova, Yanita
Tenev, Tencho
Varleva, Tonka
Duffell, Erika
Zimmermann, Ruth
Prevalence of hepatitis C in the adult population of Bulgaria: a pilot study
title Prevalence of hepatitis C in the adult population of Bulgaria: a pilot study
title_full Prevalence of hepatitis C in the adult population of Bulgaria: a pilot study
title_fullStr Prevalence of hepatitis C in the adult population of Bulgaria: a pilot study
title_full_unstemmed Prevalence of hepatitis C in the adult population of Bulgaria: a pilot study
title_short Prevalence of hepatitis C in the adult population of Bulgaria: a pilot study
title_sort prevalence of hepatitis c in the adult population of bulgaria: a pilot study
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341663/
https://www.ncbi.nlm.nih.gov/pubmed/32635926
http://dx.doi.org/10.1186/s13104-020-05158-3
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