Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines

BACKGROUND: Identifying potential resistance mechanisms while tumour cells still respond to therapy is critical to delay acquired resistance. METHODS: We generated the first comprehensive multi-omics, bulk and single-cell data in sensitive head and neck squamous cell carcinoma (HNSCC) cells to ident...

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Detalles Bibliográficos
Autores principales: Kagohara, Luciane T., Zamuner, Fernando, Davis-Marcisak, Emily F., Sharma, Gaurav, Considine, Michael, Allen, Jawara, Yegnasubramanian, Srinivasan, Gaykalova, Daria A., Fertig, Elana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341752/
https://www.ncbi.nlm.nih.gov/pubmed/32362655
http://dx.doi.org/10.1038/s41416-020-0851-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341752/
https://www.ncbi.nlm.nih.gov/pubmed/32362655
http://dx.doi.org/10.1038/s41416-020-0851-5

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