Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets

Although hepatoblastoma is the most common pediatric liver cancer, its genetic heterogeneity and therapeutic targets are not well elucidated. Therefore, we conducted a multiomics analysis, including mutatome, DNA methylome, and transcriptome analyses, of 59 hepatoblastoma samples. Based on DNA methy...

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Detalles Bibliográficos
Autores principales: Sekiguchi, Masahiro, Seki, Masafumi, Kawai, Tomoko, Yoshida, Kenichi, Yoshida, Misa, Isobe, Tomoya, Hoshino, Noriko, Shirai, Ryota, Tanaka, Mio, Souzaki, Ryota, Watanabe, Kentaro, Arakawa, Yuki, Nannya, Yasuhito, Suzuki, Hiromichi, Fujii, Yoichi, Kataoka, Keisuke, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Shimamura, Teppei, Sato, Yusuke, Sato-Otsubo, Aiko, Kimura, Shunsuke, Kubota, Yasuo, Hiwatari, Mitsuteru, Koh, Katsuyoshi, Hayashi, Yasuhide, Kanamori, Yutaka, Kasahara, Mureo, Kohashi, Kenichi, Kato, Motohiro, Yoshioka, Takako, Matsumoto, Kimikazu, Oka, Akira, Taguchi, Tomoaki, Sanada, Masashi, Tanaka, Yukichi, Miyano, Satoru, Hata, Kenichiro, Ogawa, Seishi, Takita, Junko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341754/
https://www.ncbi.nlm.nih.gov/pubmed/32656360
http://dx.doi.org/10.1038/s41698-020-0125-y

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