Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil

Omecamtiv mecarbil (OM) is a putative positive inotropic tool for treatment of systolic heart dysfunction, based on the finding that in vivo it increases the ejection fraction and in vitro it prolongs the actin-bond life time of the cardiac and slow-skeletal muscle isoforms of myosin. OM action in s...

Descripción completa

Detalles Bibliográficos
Autores principales: Governali, Serena, Caremani, Marco, Gallart, Cristina, Pertici, Irene, Stienen, Ger, Piazzesi, Gabriella, Ottenheijm, Coen, Lombardi, Vincenzo, Linari, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341760/
https://www.ncbi.nlm.nih.gov/pubmed/32636378
http://dx.doi.org/10.1038/s41467-020-17143-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341760/
https://www.ncbi.nlm.nih.gov/pubmed/32636378
http://dx.doi.org/10.1038/s41467-020-17143-2

Ejemplares similares