Cargando…

Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

Neurodegeneration is a common hallmark of individuals with hereditary defects in DNA single-strand break repair; a process regulated by poly(ADP-ribose) metabolism. Recently, mutations in the ARH3 (ADPRHL2) hydrolase that removes ADP-ribose from proteins have been associated with neurodegenerative d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hanzlikova, Hana, Prokhorova, Evgeniia, Krejcikova, Katerina, Cihlarova, Zuzana, Kalasova, Ilona, Kubovciak, Jan, Sachova, Jana, Hailstone, Richard, Brazina, Jan, Ghosh, Shereen, Cirak, Sebahattin, Gleeson, Joseph G., Ahel, Ivan, Caldecott, Keith W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341855/ https://www.ncbi.nlm.nih.gov/pubmed/32636369 http://dx.doi.org/10.1038/s41467-020-17069-9

Ejemplares similares

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication
por: Hanzlikova, Hana, et al.
Publicado: (2018)

The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
por: Hendriks, Ivo A., et al.
Publicado: (2021)

ARH Family of ADP-Ribose-Acceptor Hydrolases
por: Ishiwata-Endo, Hiroko, et al.
Publicado: (2022)

BRAT1 links Integrator and defective RNA processing with neurodegeneration
por: Cihlarova, Zuzana, et al.
Publicado: (2022)

Serine ADP-ribosylation reversal by the hydrolase ARH3
por: Fontana, Pietro, et al.
Publicado: (2017)

ADP-ribosylation of DNA and RNA()
por: Groslambert, Joséphine, et al.
Publicado: (2021)

XRCC1 prevents toxic PARP1 trapping during DNA base excision repair
por: Demin, Annie A., et al.
Publicado: (2021)

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
por: Kalasova, Ilona, et al.
Publicado: (2020)

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function
por: Breslin, Claire, et al.
Publicado: (2015)

Serine is the major residue for ADP-ribosylation upon DNA damage
por: Palazzo, Luca, et al.
Publicado: (2018)

XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair
por: Adamowicz, Marek, et al.
Publicado: (2021)

Structure of mouse ADP-ribosylhydrolase 3 (mARH3)
por: Mueller-Dieckmann, Christoph, et al.
Publicado: (2008)

Interplay of Histone Marks with Serine ADP-Ribosylation
por: Bartlett, Edward, et al.
Publicado: (2018)

Molecular Insights into Poly(ADP-ribose) Recognition and Processing
por: Žaja, Roko, et al.
Publicado: (2012)

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
por: Slade, Dea, et al.
Publicado: (2011)

Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase
por: Abplanalp, Jeannette, et al.
Publicado: (2017)

Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1
por: Polo, Luis M., et al.
Publicado: (2019)

Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin
por: Hanzlikova, Hana, et al.
Publicado: (2017)

Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice
por: Watanabe, Kizuku, et al.
Publicado: (2018)

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities
por: Barkauskaite, Eva, et al.
Publicado: (2013)

ARH1 in Health and Disease
por: Ishiwata-Endo, Hiroko, et al.
Publicado: (2020)

Mutations of the functional ARH1 allele in tumors from ARH1 heterozygous mice and cells affect ARH1 catalytic activity, cell proliferation and tumorigenesis
por: Kato, J, et al.
Publicado: (2015)

Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)
por: Eustermann, Sebastian, et al.
Publicado: (2010)

Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response
por: Beijer, Danique, et al.
Publicado: (2021)

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes
por: Gagné, Jean-Philippe, et al.
Publicado: (2008)

Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn(2+)-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase
por: Cabezas, Alicia, et al.
Publicado: (2015)

Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ
por: Kalasova, Ilona, et al.
Publicado: (2019)

Multifunctional adaptor protein Daxx interacts with chromatin-remodelling ATPase Brg1
por: Svadlenka, Jan, et al.
Publicado: (2015)

Pancreatic β-Cell Death, Regeneration and Insulin Secretion: Roles of Poly(ADP-Ribose) Polymerase and Cyclic ADP-Ribose
por: Takasawa, Shin, et al.
Publicado: (2002)

Homozygous pathogenic variant in BRAT1 associated with nonprogressive cerebellar ataxia
por: Mahjoub, Areej, et al.
Publicado: (2019)

Poly(ADP-ribose): An organizer of cellular architecture
por: Leung, Anthony K.L.
Publicado: (2014)

Poly (ADP-ribose) in the pathogenesis of Parkinson's disease
por: Lee, Yunjong, et al.
Publicado: (2014)

RNA regulation by Poly(ADP-ribose) polymerases
por: Bock, Florian J., et al.
Publicado: (2015)

Oncogenic activity of poly (ADP-ribose) glycohydrolase
por: Marques, Maud, et al.
Publicado: (2018)

Mitotic functions of poly(ADP-ribose) polymerases
por: Slade, Dea
Publicado: (2019)

The Antiviral Activities of Poly-ADP-Ribose Polymerases
por: Malgras, Mathilde, et al.
Publicado: (2021)

The role of poly (ADP-ribose) polymerase in ventilator-induced lung injury
por: Vaneker, Michiel, et al.
Publicado: (2008)

Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers
por: Tesauro, Cinzia, et al.
Publicado: (2014)

Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase
por: Ribeiro, João Meireles, et al.
Publicado: (2018)

Inhibition of Poly ADP-Ribose Glycohydrolase Sensitizes Ovarian Cancer Cells to Poly ADP-Ribose Polymerase Inhibitors and Platinum Agents
por: Matanes, Emad, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nq97u3l5e615fe1u2n54vjk9ai