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Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release

The authors present the preparation procedure and a computational model of a three‐layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(d,l-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(ε-capr...

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Autores principales: Milosevic, Miljan, Stojanovic, Dusica B., Simic, Vladimir, Grkovic, Mirjana, Bjelovic, Milos, Uskokovic, Petar S., Kojic, Milos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341868/
https://www.ncbi.nlm.nih.gov/pubmed/32636450
http://dx.doi.org/10.1038/s41598-020-68117-9
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author Milosevic, Miljan
Stojanovic, Dusica B.
Simic, Vladimir
Grkovic, Mirjana
Bjelovic, Milos
Uskokovic, Petar S.
Kojic, Milos
author_facet Milosevic, Miljan
Stojanovic, Dusica B.
Simic, Vladimir
Grkovic, Mirjana
Bjelovic, Milos
Uskokovic, Petar S.
Kojic, Milos
author_sort Milosevic, Miljan
collection PubMed
description The authors present the preparation procedure and a computational model of a three‐layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(d,l-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(ε-caprolactone) (PCL) layers. Experimental results of drug release rates from the scaffold are compared with the results of the recently introduced computational finite element (FE) models for diffusive drug release from nanofibers to the three-dimensional (3D) surrounding medium. Two different FE models are used: (1) a 3D discretized continuum and fibers represented by a simple radial one-dimensional (1D) finite elements, and (2) a 3D continuum discretized by composite smeared finite elements (CSFEs) containing the fiber smeared and surrounding domains. Both models include the effects of polymer degradation and hydrophobicity (as partitioning) of the drug at the fiber/surrounding interface. The CSFE model includes a volumetric fraction of fibers and diameter distribution, and is additionally enhanced by using correction function to improve the accuracy of the model. The computational results are validated on Rhodamine B (fluorescent drug l) and other hydrophilic drugs. Agreement with experimental results proves that numerical models can serve as efficient tools for drug release to the surrounding porous medium or biological tissue. It is demonstrated that the introduced three-layered scaffold delays the drug release process and can be used for the time-controlled release of drugs in postoperative therapy.
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spelling pubmed-73418682020-07-09 Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release Milosevic, Miljan Stojanovic, Dusica B. Simic, Vladimir Grkovic, Mirjana Bjelovic, Milos Uskokovic, Petar S. Kojic, Milos Sci Rep Article The authors present the preparation procedure and a computational model of a three‐layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(d,l-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(ε-caprolactone) (PCL) layers. Experimental results of drug release rates from the scaffold are compared with the results of the recently introduced computational finite element (FE) models for diffusive drug release from nanofibers to the three-dimensional (3D) surrounding medium. Two different FE models are used: (1) a 3D discretized continuum and fibers represented by a simple radial one-dimensional (1D) finite elements, and (2) a 3D continuum discretized by composite smeared finite elements (CSFEs) containing the fiber smeared and surrounding domains. Both models include the effects of polymer degradation and hydrophobicity (as partitioning) of the drug at the fiber/surrounding interface. The CSFE model includes a volumetric fraction of fibers and diameter distribution, and is additionally enhanced by using correction function to improve the accuracy of the model. The computational results are validated on Rhodamine B (fluorescent drug l) and other hydrophilic drugs. Agreement with experimental results proves that numerical models can serve as efficient tools for drug release to the surrounding porous medium or biological tissue. It is demonstrated that the introduced three-layered scaffold delays the drug release process and can be used for the time-controlled release of drugs in postoperative therapy. Nature Publishing Group UK 2020-07-07 /pmc/articles/PMC7341868/ /pubmed/32636450 http://dx.doi.org/10.1038/s41598-020-68117-9 Text en © The Author(s) 2020, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Milosevic, Miljan
Stojanovic, Dusica B.
Simic, Vladimir
Grkovic, Mirjana
Bjelovic, Milos
Uskokovic, Petar S.
Kojic, Milos
Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release
title Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release
title_full Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release
title_fullStr Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release
title_full_unstemmed Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release
title_short Preparation and modeling of three‐layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release
title_sort preparation and modeling of three‐layered pcl/plga/pcl fibrous scaffolds for prolonged drug release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341868/
https://www.ncbi.nlm.nih.gov/pubmed/32636450
http://dx.doi.org/10.1038/s41598-020-68117-9
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