Single-cell RNA sequencing reveals that lung mesenchymal progenitor cells in IPF exhibit pathological features early in their differentiation trajectory

In Idiopathic Pulmonary Fibrosis (IPF), there is unrelenting scarring of the lung mediated by pathological mesenchymal progenitor cells (MPCs) that manifest autonomous fibrogenicity in xenograft models. To determine where along their differentiation trajectory IPF MPCs acquire fibrogenic properties,...

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Detalles Bibliográficos
Autores principales: Beisang, Daniel J., Smith, Karen, Yang, Libang, Benyumov, Alexey, Gilbertsen, Adam, Herrera, Jeremy, Lock, Eric, Racila, Emilian, Forster, Colleen, Sandri, Brian J., Henke, Craig A., Bitterman, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341888/
https://www.ncbi.nlm.nih.gov/pubmed/32636398
http://dx.doi.org/10.1038/s41598-020-66630-5

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