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Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol

Biosynthesis of glycosylphosphatidylinositol (GPI) is required for anchoring proteins to the plasma membrane, and is essential for the integrity of the fungal cell wall. Here, we use a reporter gene-based screen in Saccharomyces cerevisiae for the discovery of antifungal inhibitors of GPI-anchoring...

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Detalles Bibliográficos
Autores principales:	Fu, Yue, Estoppey, David, Roggo, Silvio, Pistorius, Dominik, Fuchs, Florian, Studer, Christian, Ibrahim, Ashraf S., Aust, Thomas, Grandjean, Frederic, Mihalic, Manuel, Memmert, Klaus, Prindle, Vivian, Richard, Etienne, Riedl, Ralph, Schuierer, Sven, Weber, Eric, Hunziker, Jürg, Petersen, Frank, Tao, Jianshi, Hoepfner, Dominic
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341893/ https://www.ncbi.nlm.nih.gov/pubmed/32636417 http://dx.doi.org/10.1038/s41467-020-17221-5

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