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The World Goes Bats: Living Longer and Tolerating Viruses

For centuries, people believed that bats possessed sinister powers. Bats are thought to be ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most recently SARS-CoV-2 coronavirus. However, bats themselves tolerate these viruses without ill effects. The second power...

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Detalles Bibliográficos
Autores principales: Gorbunova, Vera, Seluanov, Andrei, Kennedy, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/
https://www.ncbi.nlm.nih.gov/pubmed/32640245
http://dx.doi.org/10.1016/j.cmet.2020.06.013
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author Gorbunova, Vera
Seluanov, Andrei
Kennedy, Brian K.
author_facet Gorbunova, Vera
Seluanov, Andrei
Kennedy, Brian K.
author_sort Gorbunova, Vera
collection PubMed
description For centuries, people believed that bats possessed sinister powers. Bats are thought to be ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most recently SARS-CoV-2 coronavirus. However, bats themselves tolerate these viruses without ill effects. The second power that bats have is their longevity. Bats live much longer than similar-sized land mammals. Here we review how bats’ ability to control inflammation may be contributing to their longevity. The underlying mechanisms may hold clues to developing new treatments for age-related diseases. Now may be the time to use science to exploit the secret powers of bats for human benefit.
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spelling pubmed-73419512020-07-08 The World Goes Bats: Living Longer and Tolerating Viruses Gorbunova, Vera Seluanov, Andrei Kennedy, Brian K. Cell Metab Perspective For centuries, people believed that bats possessed sinister powers. Bats are thought to be ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most recently SARS-CoV-2 coronavirus. However, bats themselves tolerate these viruses without ill effects. The second power that bats have is their longevity. Bats live much longer than similar-sized land mammals. Here we review how bats’ ability to control inflammation may be contributing to their longevity. The underlying mechanisms may hold clues to developing new treatments for age-related diseases. Now may be the time to use science to exploit the secret powers of bats for human benefit. Elsevier Inc. 2020-07-07 2020-07-07 /pmc/articles/PMC7341951/ /pubmed/32640245 http://dx.doi.org/10.1016/j.cmet.2020.06.013 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Perspective
Gorbunova, Vera
Seluanov, Andrei
Kennedy, Brian K.
The World Goes Bats: Living Longer and Tolerating Viruses
title The World Goes Bats: Living Longer and Tolerating Viruses
title_full The World Goes Bats: Living Longer and Tolerating Viruses
title_fullStr The World Goes Bats: Living Longer and Tolerating Viruses
title_full_unstemmed The World Goes Bats: Living Longer and Tolerating Viruses
title_short The World Goes Bats: Living Longer and Tolerating Viruses
title_sort world goes bats: living longer and tolerating viruses
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/
https://www.ncbi.nlm.nih.gov/pubmed/32640245
http://dx.doi.org/10.1016/j.cmet.2020.06.013
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