The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. Here, through a genome-wide mutant screen of human antigen-presenting cells, we show that...

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Detalles Bibliográficos
Autores principales: Alix, Eric, Godlee, Camilla, Cerny, Ondrej, Blundell, Samkeliso, Tocci, Romina, Matthews, Sophie, Liu, Mei, Pruneda, Jonathan N., Swatek, Kirby N., Komander, David, Sleap, Tabitha, Holden, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342019/
https://www.ncbi.nlm.nih.gov/pubmed/32526160
http://dx.doi.org/10.1016/j.chom.2020.04.024

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