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转录因子T-bet在外周T细胞淋巴瘤患者中的表达及其预后意义初探
OBJECTIVE: To evaluate the expression of transcription factor T-bet (T-box expressed in T cells) and explore its effects on prognosis in peripheral T-cell lymphoma (PTCL). METHODS: This study included 109 previously untreated patients diagnosed with PTCL in the pathology system at Peking Union Medic...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
Publicado: |
Editorial office of Chinese Journal of Hematology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342106/ https://www.ncbi.nlm.nih.gov/pubmed/27719721 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2016.09.010 |
Sumario: | OBJECTIVE: To evaluate the expression of transcription factor T-bet (T-box expressed in T cells) and explore its effects on prognosis in peripheral T-cell lymphoma (PTCL). METHODS: This study included 109 previously untreated patients diagnosed with PTCL in the pathology system at Peking Union Medical College Hospital from 2007 to 2013. Formalin-fixed, paraffin-embedded blocks and clinical information of these patients were collected. T-bet expression was examined by immunohistochemical stain, while its relationship with clinical feature and prognosis was analyzed. RESULTS: 109 PTCL patients included 60 PTCL-not other specified (PTCL-NOS) cases and 18 NK/T-cell lymphoma. The positive rate of T-bet was 42.2% overall, 43.3% in PTCL-NOS and 44.4% in NK/T lymphoma. T-bet high expression wasn't correlated with OS in PTCL patients (P=0.586) by Kaplan-Meier analysis. Further stratification by pathological subgroup implied a correlation of T-bet high expression with better survival in NK/T lymphoma (P=0.004), but not in PTCL-NOS (P=0.309). Multivariate analysis confirmed that high ECOG score (≥2) was an independent predictor of overall survival (HR=5.907, 95%CI 2.399~14.549, P<0.001). CONCLUSION: T-bet was detected in several PTCL subgroups with diversities, which is positively correlated with overall survival in NK/T-cell lymphoma. |
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