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成人儿童型滤泡淋巴瘤五例临床观察
OBJECTIVE: To investigate the characteristics in pathological diagnosis, clinical features, treatment and prognosis of adult patients with pediatric-type follicular lymphoma (PTFL). METHODS: The clinical and pathological features, laboratory examination, diagnosis and treatment, follow-up results of...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
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Editorial office of Chinese Journal of Hematology
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342233/ https://www.ncbi.nlm.nih.gov/pubmed/31207704 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.05.009 |
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collection | PubMed |
description | OBJECTIVE: To investigate the characteristics in pathological diagnosis, clinical features, treatment and prognosis of adult patients with pediatric-type follicular lymphoma (PTFL). METHODS: The clinical and pathological features, laboratory examination, diagnosis and treatment, follow-up results of 5 adult PTFL patients admitted in Jiangsu Province Hospital were retrospectively analyzed, and literature review was conducted in combination with related reports. RESULTS: All 5 patients developed PTFL in their adulthood with a median age of 22 years old (15–33 years). The initial inanifestation of the disease was local painless lymphadenopathy with no fever, night sweats, emaciation or other systemic B symptoms. Pathological characteristics including typical large follicular structures and high proliferation index were found. Meanwhile, additional clonal rearrangement of immunoglobulin heavy chain gene was observed. However, there was no BCL-2 expression in histochemistry as well as BCL-2 gene abnormality in fluorescence in situ hybridization among these PTFL patients. These adult PTFL patients were all in stage Ⅰ-Ⅱ of the disease. For treatment, they were only treated with local surgical excision after diagnosis while didn't receive subsequent local radiotherapy or systemic immunochemotherapy. During a median follow-up of 27 months, the 5 cases of PTFL kept in a state of sustained complete remission. CONCLUSION: Adult-onset PTFL is characterized by high pathological proliferation index, while no BCL-2 expression or BCL-2 gene abnormality. Besides, PTFL is clinically manifested as a localized disease that can achieve a quite good prognosis through local surgical intervention. The aforementioned attributes of PTFL are distinctly different from classic adult follicular lymphoma. |
format | Online Article Text |
id | pubmed-7342233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Editorial office of Chinese Journal of Hematology |
record_format | MEDLINE/PubMed |
spelling | pubmed-73422332020-07-16 成人儿童型滤泡淋巴瘤五例临床观察 Zhonghua Xue Ye Xue Za Zhi 论著 OBJECTIVE: To investigate the characteristics in pathological diagnosis, clinical features, treatment and prognosis of adult patients with pediatric-type follicular lymphoma (PTFL). METHODS: The clinical and pathological features, laboratory examination, diagnosis and treatment, follow-up results of 5 adult PTFL patients admitted in Jiangsu Province Hospital were retrospectively analyzed, and literature review was conducted in combination with related reports. RESULTS: All 5 patients developed PTFL in their adulthood with a median age of 22 years old (15–33 years). The initial inanifestation of the disease was local painless lymphadenopathy with no fever, night sweats, emaciation or other systemic B symptoms. Pathological characteristics including typical large follicular structures and high proliferation index were found. Meanwhile, additional clonal rearrangement of immunoglobulin heavy chain gene was observed. However, there was no BCL-2 expression in histochemistry as well as BCL-2 gene abnormality in fluorescence in situ hybridization among these PTFL patients. These adult PTFL patients were all in stage Ⅰ-Ⅱ of the disease. For treatment, they were only treated with local surgical excision after diagnosis while didn't receive subsequent local radiotherapy or systemic immunochemotherapy. During a median follow-up of 27 months, the 5 cases of PTFL kept in a state of sustained complete remission. CONCLUSION: Adult-onset PTFL is characterized by high pathological proliferation index, while no BCL-2 expression or BCL-2 gene abnormality. Besides, PTFL is clinically manifested as a localized disease that can achieve a quite good prognosis through local surgical intervention. The aforementioned attributes of PTFL are distinctly different from classic adult follicular lymphoma. Editorial office of Chinese Journal of Hematology 2019-05 /pmc/articles/PMC7342233/ /pubmed/31207704 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.05.009 Text en 2019年版权归中华医学会所有 http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution 3.0 License (CC-BY-NC). The Copyright own by Publisher. Without authorization, shall not reprint, except this publication article, shall not use this publication format design. Unless otherwise stated, all articles published in this journal do not represent the views of the Chinese Medical Association or the editorial board of this journal. |
spellingShingle | 论著 成人儿童型滤泡淋巴瘤五例临床观察 |
title | 成人儿童型滤泡淋巴瘤五例临床观察 |
title_full | 成人儿童型滤泡淋巴瘤五例临床观察 |
title_fullStr | 成人儿童型滤泡淋巴瘤五例临床观察 |
title_full_unstemmed | 成人儿童型滤泡淋巴瘤五例临床观察 |
title_short | 成人儿童型滤泡淋巴瘤五例临床观察 |
title_sort | 成人儿童型滤泡淋巴瘤五例临床观察 |
topic | 论著 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342233/ https://www.ncbi.nlm.nih.gov/pubmed/31207704 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.05.009 |
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