Cargando…

Effects of Dexmedetomidine on the Pharmacokinetics of Dezocine, Midazolam and Its Metabolite 1-Hydroxymidazolam in Beagles by UPLC-MS/MS

OBJECTIVE: We developed and validated a sensitive and reliable UPLC-MS/MS method for simultaneous determination of dezocine (DEZ), midazolam (MDZ) and its metabolite 1-hydroxymidazolam (1-OH-MDZ) in beagle plasma and investigated the effect of dexmedetomidine (DEX) on the pharmacokinetics of DEZ, MD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Wei, Li, Shuang-long, Zhao, Ti, Li, Le, Xing, Wen-bin, Qiu, Xiang-jun, Zhang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342499/ https://www.ncbi.nlm.nih.gov/pubmed/32753841 http://dx.doi.org/10.2147/DDDT.S254055

Ejemplares similares

Simultaneous Determination of Celecoxib, Dezocine and Dexmedetomidine in Beagle Plasma Using UPLC-MS/MS Method and the Application in Pharmacokinetics
por: Hu, Jie, et al.
Publicado: (2021)

Effects of Dexmedetomidine on the Pharmacokinetics of Parecoxib and Its Metabolite Valdecoxib in Beagles by UPLC-MS/MS
por: Hu, Jie, et al.
Publicado: (2020)

LC-MS/MS Method for Simultaneous Quantification of Dexmedetomidine, Dezocine, and Midazolam in Rat Plasma and Its Application to Their Pharmacokinetic Study
por: Cui, Wenjuan, et al.
Publicado: (2018)

Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study
por: Li, Shuang-long, et al.
Publicado: (2020)

Determination of Tropifexor in Beagle Dog Plasma by UPLC-MS/MS and Its Application in Pharmacokinetics
por: Su, Yan-Ding, et al.
Publicado: (2022)

The Effect of Posaconazole and Isavuconazole on the Pharmacokinetics of Erdafitinib in Beagle Dogs by UPLC-MS/MS
por: Ruan, Lan-hong, et al.
Publicado: (2021)

The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique
por: Wang, Hui-jun, et al.
Publicado: (2021)

Quantitation of Apremilast in Beagle Dogs Plasma by UPLC-MS-MS and Its Application to Pharmacokinetic Studies
por: Xiong, Wei, et al.
Publicado: (2021)

Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study
por: Wang, Meng-Jie, et al.
Publicado: (2021)

The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique [Corrigendum]
Publicado: (2023)

Pharmacokinetics and metabolism of icaritin in rats by UPLC‐MS/MS
por: Huang, Zhen‐Wu, et al.
Publicado: (2019)

Pharmacokinetic and Metabolism Studies of Curculigoside C by UPLC-MS/MS and UPLC-QTOF-MS
por: Wu, Di, et al.
Publicado: (2018)

UPLC-MS/MS Measurement of the Effect of Isavuconazole, Itraconazole and Fluconazole on the Pharmacokinetics of Selinexor in Rats
por: Li, Shuang-long, et al.
Publicado: (2020)

Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices
por: Balk, Monika, et al.
Publicado: (2017)

Development and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect
por: Xu, Yuxiang, et al.
Publicado: (2023)

Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application
por: Li, Shuang-long, et al.
Publicado: (2020)

Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS
por: Li, Ming, et al.
Publicado: (2022)

UPLC-MS/MS method for Icariin and metabolites in whole blood of C57 mice: development, validation, and pharmacokinetics study
por: Liu, Wei, et al.
Publicado: (2023)

Pharmacokinetic and Metabolism Studies of 12-Riboside-Pseudoginsengenin DQ by UPLC-MS/MS and UPLC-QTOF-MS(E)
por: Wang, Zhenzhou, et al.
Publicado: (2018)

Application of a UPLC–MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma()
por: Liu, Hui, et al.
Publicado: (2016)

Pharmacokinetics of Herb-Drug Interactions of Plumbagin and Tazemetostat in Rats by UPLC-MS/MS
por: Li, Heng, et al.
Publicado: (2022)

Pharmacokinetics of Dibutyl Phthalate (DBP) in the Rat Determined by UPLC-MS/MS
por: Chang, Li-Wen, et al.
Publicado: (2013)

Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood
por: Shao, Lingjiu, et al.
Publicado: (2018)

Pharmacokinetic Analysis of Diosgenin in Rat Plasma by a UPLC-MS/MS Approach
por: Liu, Pei, et al.
Publicado: (2022)

Effect of Baicalein on the Pharmacokinetics of Cilostazol and Its Two Metabolites in Rat Plasma Using UPLC-MS/MS Method
por: Weng, Qinghua, et al.
Publicado: (2022)

Effects of Xuesaitong on the Pharmacokinetics of Losartan: An In Vivo UPLC-MS/MS Study
por: Ma, Weina, et al.
Publicado: (2019)

Pharmacokinetics and Bioavailability Study of Tubeimoside I in ICR Mice by UPLC-MS/MS
por: Chen, Lianguo, et al.
Publicado: (2018)

Plasma Pharmacokinetic Determination of Canagliflozin and Its Metabolites in a Type 2 Diabetic Rat Model by UPLC-MS/MS
por: Dong, Song-tao, et al.
Publicado: (2018)

Trace quantification of GL-V9 and its glucuronide metabolites (5-O-glucuronide GL-V9) in Beagle dog plasma by UPLC–MS/MS and its application to a pharmacokinetic study
por: Zhang, Xuefeng, et al.
Publicado: (2023)

Analysis of Flavonoid Metabolites in Chaenomeles Petals Using UPLC-ESI-MS/MS
por: Shen, Ting, et al.
Publicado: (2020)

Genistein Exposure Interferes with Pharmacokinetics of Celecoxib in SD Male Rats by UPLC-MS/MS
por: Zheng, Xiang, et al.
Publicado: (2017)

Analysis of Flavonoid Metabolites in Buckwheat Leaves Using UPLC-ESI-MS/MS
por: Li, Jing, et al.
Publicado: (2019)

Enantiospecific pharmacokinetics of intravenous dexmedetomidine in beagles
por: Levionnois, Olivier Louis, et al.
Publicado: (2022)

Simultaneous Determination and Pharmacokinetics of Peimine and Peiminine in Beagle Dog Plasma by UPLC-MS/MS after the Oral Administration of Fritillariae ussuriensis Maxim and Fritillariae thunbergii Miq Powder
por: Wang, Zhibin, et al.
Publicado: (2018)

Eco-Friendly UPLC–MS/MS Method for Determination of a Fostamatinib Metabolite, Tamatinib, in Plasma: Pharmacokinetic Application in Rats
por: Ezzeldin, Essam, et al.
Publicado: (2021)

Pharmacokinetics, Bioavailability, and Tissue Distribution Study of Angoroside C and Its Metabolite Ferulic Acid in Rat Using UPLC-MS/MS
por: Zhang, Chenning, et al.
Publicado: (2018)

Inhibitory effect of Schisandrin on the pharmacokinetics of poziotinib in vivo and in vitro by UPLC‐MS/MS
por: Wang, Shuanghu, et al.
Publicado: (2023)

UPLC-MS/MS Technology for the Quantitative Methodology and Pharmacokinetic Analysis of Voxtalisib in Rat Plasma
por: Li, Qingqing, et al.
Publicado: (2022)

Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies
por: Chen, Mengchun, et al.
Publicado: (2020)

Metabolite Profiling and Distribution of Militarine in Rats Using UPLC-Q-TOF-MS/MS
por: Li, Limin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_oq6sbfd0bkh94cegojbkj12idk