获得性再生障碍性贫血克隆性进展为骨髓增生异常综合征/急性髓系白血病：19例临床分析及文献复习

OBJECTIVE: To analyze the clinical features of clonal evolution of acquired aplastic anemia (AA) into myelodysplastic syndrome/acute myeloid leukemia (AML) and review of literatures. METHODS: AA developing MDS/AML patients between December 1994 and December 2011 enrolled into this study to analyze t...

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Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial office of Chinese Journal of Hematology 2015
Materias:
论著
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342519/
https://www.ncbi.nlm.nih.gov/pubmed/25854465
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2015.03.009
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collection PubMed
description OBJECTIVE: To analyze the clinical features of clonal evolution of acquired aplastic anemia (AA) into myelodysplastic syndrome/acute myeloid leukemia (AML) and review of literatures. METHODS: AA developing MDS/AML patients between December 1994 and December 2011 enrolled into this study to analyze their clinical characteristics. RESULTS: During the median follow-up of 49(15–97) months, 19 patients evolved to MDS/AML, of whom 10, 8 and 1 were from VSAA, SAA and NSAA subgroups, respectively. The median G-CSF therapy was 270(29–510) days. There were monosomy 7 in 11(57.9%) of 19 patients with AA evolved to MDS/AML. The median AA evolved to MDS/AML was 33(11–88) months. The median MDS/AML transformation in responders(54.2 months) was significantly longer than of non-responders (25.7 months,P<0.01). CONCLUSION: AA patients could evolved into MDS/AML concomitant with abnormal karotype and worse prognosis.
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spelling pubmed-73425192020-07-16 获得性再生障碍性贫血克隆性进展为骨髓增生异常综合征/急性髓系白血病：19例临床分析及文献复习 Zhonghua Xue Ye Xue Za Zhi 论著 OBJECTIVE: To analyze the clinical features of clonal evolution of acquired aplastic anemia (AA) into myelodysplastic syndrome/acute myeloid leukemia (AML) and review of literatures. METHODS: AA developing MDS/AML patients between December 1994 and December 2011 enrolled into this study to analyze their clinical characteristics. RESULTS: During the median follow-up of 49(15–97) months, 19 patients evolved to MDS/AML, of whom 10, 8 and 1 were from VSAA, SAA and NSAA subgroups, respectively. The median G-CSF therapy was 270(29–510) days. There were monosomy 7 in 11(57.9%) of 19 patients with AA evolved to MDS/AML. The median AA evolved to MDS/AML was 33(11–88) months. The median MDS/AML transformation in responders(54.2 months) was significantly longer than of non-responders (25.7 months,P<0.01). CONCLUSION: AA patients could evolved into MDS/AML concomitant with abnormal karotype and worse prognosis. Editorial office of Chinese Journal of Hematology 2015-03 /pmc/articles/PMC7342519/ /pubmed/25854465 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2015.03.009 Text en 2015年版权归中华医学会所有 http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution 3.0 License (CC-BY-NC). The Copyright own by Publisher. Without authorization, shall not reprint, except this publication article, shall not use this publication format design. Unless otherwise stated, all articles published in this journal do not represent the views of the Chinese Medical Association or the editorial board of this journal.
spellingShingle 论著
获得性再生障碍性贫血克隆性进展为骨髓增生异常综合征/急性髓系白血病：19例临床分析及文献复习
title 获得性再生障碍性贫血克隆性进展为骨髓增生异常综合征/急性髓系白血病：19例临床分析及文献复习
title_full 获得性再生障碍性贫血克隆性进展为骨髓增生异常综合征/急性髓系白血病：19例临床分析及文献复习
title_fullStr 获得性再生障碍性贫血克隆性进展为骨髓增生异常综合征/急性髓系白血病：19例临床分析及文献复习
title_full_unstemmed 获得性再生障碍性贫血克隆性进展为骨髓增生异常综合征/急性髓系白血病：19例临床分析及文献复习
title_short 获得性再生障碍性贫血克隆性进展为骨髓增生异常综合征/急性髓系白血病：19例临床分析及文献复习
title_sort 获得性再生障碍性贫血克隆性进展为骨髓增生异常综合征/急性髓系白血病：19例临床分析及文献复习
topic 论著
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342519/
https://www.ncbi.nlm.nih.gov/pubmed/25854465
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2015.03.009
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