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异基因造血干细胞移植后出血性膀胱炎的临床特征及高危因素分析

OBJECTIVE: To explore the relative risk factors, clinical intervention and prognosis of hemorrhagic cystitis (HC) in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: From January 1 2010 to May 31 2017, 425 patients with allo-HSCT received a retrospective analysi...

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Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial office of Chinese Journal of Hematology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342539/
https://www.ncbi.nlm.nih.gov/pubmed/30929383
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.03.004
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collection PubMed
description OBJECTIVE: To explore the relative risk factors, clinical intervention and prognosis of hemorrhagic cystitis (HC) in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: From January 1 2010 to May 31 2017, 425 patients with allo-HSCT received a retrospective analysis. RESULTS: ①Among the 425 patients, 262 were male and 163 were female. The median age was 26 (2–56) years old. There were 138 cases of acute myeloid leukemia (AML), 96 cases of acute lymphoblastic leukemia (ALL), 29 cases of myelodysplastic syndrome (MDS), 98 cases of severe aplastic anemia (SAA) and 64 cases of chronic myeloid leukemia (CML). 221 cases of sibling match transplantation, 89 cases of unrelated donor transplantation and 115 cases of haplotype transplantation. ②108 patients (25.41%) developed HC, with the median time of onset of 32 (3–243) days and the median duration of 20 (3–93) days; 33 cases (30.56%) were grade Ⅰ, 49 cases of grade Ⅱ (45.36%), 21 cases (19.44%) of grade Ⅲ, and 5 cases (4.63%) of grade Ⅳ. ③103 cases of HC were cured, 5 patients were ineffective, 12 patients died and died of transplantation related complications (infection, recurrence, severe acute GVHD, secondary implant failure). ④Univariate analysis showed that age < 30, type of transplantation, CMV and acute GVHD were associated with the occurrence of HC after allo-HSCT. Multivariate analysis showed that acute GVHD was an independent risk factor for HC after allo-HSCT. CONCLUSION: Prognosis of HC after allo-HSCT was better after timely treatment.
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spelling pubmed-73425392020-07-16 异基因造血干细胞移植后出血性膀胱炎的临床特征及高危因素分析 Zhonghua Xue Ye Xue Za Zhi 论著 OBJECTIVE: To explore the relative risk factors, clinical intervention and prognosis of hemorrhagic cystitis (HC) in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: From January 1 2010 to May 31 2017, 425 patients with allo-HSCT received a retrospective analysis. RESULTS: ①Among the 425 patients, 262 were male and 163 were female. The median age was 26 (2–56) years old. There were 138 cases of acute myeloid leukemia (AML), 96 cases of acute lymphoblastic leukemia (ALL), 29 cases of myelodysplastic syndrome (MDS), 98 cases of severe aplastic anemia (SAA) and 64 cases of chronic myeloid leukemia (CML). 221 cases of sibling match transplantation, 89 cases of unrelated donor transplantation and 115 cases of haplotype transplantation. ②108 patients (25.41%) developed HC, with the median time of onset of 32 (3–243) days and the median duration of 20 (3–93) days; 33 cases (30.56%) were grade Ⅰ, 49 cases of grade Ⅱ (45.36%), 21 cases (19.44%) of grade Ⅲ, and 5 cases (4.63%) of grade Ⅳ. ③103 cases of HC were cured, 5 patients were ineffective, 12 patients died and died of transplantation related complications (infection, recurrence, severe acute GVHD, secondary implant failure). ④Univariate analysis showed that age < 30, type of transplantation, CMV and acute GVHD were associated with the occurrence of HC after allo-HSCT. Multivariate analysis showed that acute GVHD was an independent risk factor for HC after allo-HSCT. CONCLUSION: Prognosis of HC after allo-HSCT was better after timely treatment. Editorial office of Chinese Journal of Hematology 2019-03 /pmc/articles/PMC7342539/ /pubmed/30929383 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.03.004 Text en 2019年版权归中华医学会所有 http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution 3.0 License (CC-BY-NC). The Copyright own by Publisher. Without authorization, shall not reprint, except this publication article, shall not use this publication format design. Unless otherwise stated, all articles published in this journal do not represent the views of the Chinese Medical Association or the editorial board of this journal.
spellingShingle 论著
异基因造血干细胞移植后出血性膀胱炎的临床特征及高危因素分析
title 异基因造血干细胞移植后出血性膀胱炎的临床特征及高危因素分析
title_full 异基因造血干细胞移植后出血性膀胱炎的临床特征及高危因素分析
title_fullStr 异基因造血干细胞移植后出血性膀胱炎的临床特征及高危因素分析
title_full_unstemmed 异基因造血干细胞移植后出血性膀胱炎的临床特征及高危因素分析
title_short 异基因造血干细胞移植后出血性膀胱炎的临床特征及高危因素分析
title_sort 异基因造血干细胞移植后出血性膀胱炎的临床特征及高危因素分析
topic 论著
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342539/
https://www.ncbi.nlm.nih.gov/pubmed/30929383
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.03.004
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