Downregulation of RRM2 Attenuates Retroperitoneal Liposarcoma Progression via the Akt/mTOR/4EBP1 Pathway: Clinical, Biological, and Therapeutic Significance

BACKGROUND: Retroperitoneal liposarcoma (RLPS) is a rare tumor with high recurrence rate. Ribonucleotide reductase small subunit M2 (RRM2) protein is essential for DNA synthesis and replication. Our previous study has demonstrated that RRM2 downregulation inhibited the proliferation of RLPS cells, b...

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Detalles Bibliográficos
Autores principales: Zhang, Sha, Yan, Liang, Cui, Can, Wang, Zhen, Wu, Jianhui, Lv, Ang, Zhao, Min, Dong, Bin, Zhang, Wenlong, Guan, Xiaoya, Tian, Xiuyun, Hao, Chunyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342604/
https://www.ncbi.nlm.nih.gov/pubmed/32753891
http://dx.doi.org/10.2147/OTT.S246613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342604/
https://www.ncbi.nlm.nih.gov/pubmed/32753891
http://dx.doi.org/10.2147/OTT.S246613

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