CD4(+)/CD8(−)T-大颗粒淋巴细胞白血病一例报告并文献复习

OBJECTIVE: Presenting the clinical features of one patient with CD4(+)/CD8(−)T-cell large granular lymphocytic leukemia, to improve the understanding of the disease. METHODS: Clinical data of one patient hospitalized for skin rush and leukocytosis were analyzed, and the related literatures were reviewed. RESULTS: The patient was hospitalized for skin rush and leukocytosis. Routine blood test showed remarkable elevated white blood cell counts and mild anemia. Subsequent hematological examination led to a diagnosis of T-cell large granular lymphocytic leukemia with CD4 (+)/CD8(−)immunophenontype. CONCLUSION: CD3 (+)/CD4(+)/CD8(−)T-cell large granular lymphocytic leukemia is a kind of variant subtype, and is relatively rare, it has different clinical features with classic CD3(+)/CD4(−)/CD8(+)/TCRαβ(+) T-cell large granular lymphocytic leukemia, so differentiating diagnosis is of great importance.