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修订的国际分期系统(R-ISS)在初诊多发性骨髓瘤患者预后判断中的意义

OBJECTIVE: To assess the prognostic value of revised international staging system (R-ISS) for multiple myeloma (MM) in real world. METHODS: A total of 202 newly diagnosis symptomatic MM patients were enrolled from May 2010 to April 2015 and the clinical data were retrospectively analyzed. All the pa...

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Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial office of Chinese Journal of Hematology 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342976/
https://www.ncbi.nlm.nih.gov/pubmed/28655089
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2017.06.003
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collection PubMed
description OBJECTIVE: To assess the prognostic value of revised international staging system (R-ISS) for multiple myeloma (MM) in real world. METHODS: A total of 202 newly diagnosis symptomatic MM patients were enrolled from May 2010 to April 2015 and the clinical data were retrospectively analyzed. All the patients received at least four courses of bortezomib-based or thalidomide-based induction therapy. RESULTS: With a median follow-up of 31 months, the cohort included 56 cases in R-ISSⅠ, 108 in R-ISS Ⅱ, and 38 in R-ISS Ⅲ, and the median OS was not reached/61/38 months, respectively (P=0.001). According to the ISS system, 62 patients were classified in ISS-Ⅰ, 70 in ISS-Ⅱ and 70 in ISS-Ⅲ, with the median OS was 58, 52 and 40 months, respectively (P=0.001). The relative risk (HR) of R-ISS stage Ⅲ vs Ⅰ, Ⅱ vs Ⅰ were 9.606 (P=0.008) and 4.038 (P=0.029). The HR of Ⅲ vs Ⅰ, Ⅱ vs Ⅰ of ISS system were 4.127 (P=0.070) and 2.877 (P=0.005). In the subgroup analysis, R-ISS predicted survival for patients who were not transplanted (P=0.003), receiving bortezomib-based therapy (P=0.010), and patients younger than 65 years (P=0.001). CONCLUSION: R-ISS system could better predict prognosis for OS in unselected nonclinical trial myeloma patients than ISS system, especially for the younger patients, patients with bortezomib-based therapy, and patients without transplantation.
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spelling pubmed-73429762020-07-16 修订的国际分期系统(R-ISS)在初诊多发性骨髓瘤患者预后判断中的意义 Zhonghua Xue Ye Xue Za Zhi 论著 OBJECTIVE: To assess the prognostic value of revised international staging system (R-ISS) for multiple myeloma (MM) in real world. METHODS: A total of 202 newly diagnosis symptomatic MM patients were enrolled from May 2010 to April 2015 and the clinical data were retrospectively analyzed. All the patients received at least four courses of bortezomib-based or thalidomide-based induction therapy. RESULTS: With a median follow-up of 31 months, the cohort included 56 cases in R-ISSⅠ, 108 in R-ISS Ⅱ, and 38 in R-ISS Ⅲ, and the median OS was not reached/61/38 months, respectively (P=0.001). According to the ISS system, 62 patients were classified in ISS-Ⅰ, 70 in ISS-Ⅱ and 70 in ISS-Ⅲ, with the median OS was 58, 52 and 40 months, respectively (P=0.001). The relative risk (HR) of R-ISS stage Ⅲ vs Ⅰ, Ⅱ vs Ⅰ were 9.606 (P=0.008) and 4.038 (P=0.029). The HR of Ⅲ vs Ⅰ, Ⅱ vs Ⅰ of ISS system were 4.127 (P=0.070) and 2.877 (P=0.005). In the subgroup analysis, R-ISS predicted survival for patients who were not transplanted (P=0.003), receiving bortezomib-based therapy (P=0.010), and patients younger than 65 years (P=0.001). CONCLUSION: R-ISS system could better predict prognosis for OS in unselected nonclinical trial myeloma patients than ISS system, especially for the younger patients, patients with bortezomib-based therapy, and patients without transplantation. Editorial office of Chinese Journal of Hematology 2017-06 /pmc/articles/PMC7342976/ /pubmed/28655089 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2017.06.003 Text en 2017年版权归中华医学会所有 http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution 3.0 License (CC-BY-NC). The Copyright own by Publisher. Without authorization, shall not reprint, except this publication article, shall not use this publication format design. Unless otherwise stated, all articles published in this journal do not represent the views of the Chinese Medical Association or the editorial board of this journal.
spellingShingle 论著
修订的国际分期系统(R-ISS)在初诊多发性骨髓瘤患者预后判断中的意义
title 修订的国际分期系统(R-ISS)在初诊多发性骨髓瘤患者预后判断中的意义
title_full 修订的国际分期系统(R-ISS)在初诊多发性骨髓瘤患者预后判断中的意义
title_fullStr 修订的国际分期系统(R-ISS)在初诊多发性骨髓瘤患者预后判断中的意义
title_full_unstemmed 修订的国际分期系统(R-ISS)在初诊多发性骨髓瘤患者预后判断中的意义
title_short 修订的国际分期系统(R-ISS)在初诊多发性骨髓瘤患者预后判断中的意义
title_sort 修订的国际分期系统(r-iss)在初诊多发性骨髓瘤患者预后判断中的意义
topic 论著
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342976/
https://www.ncbi.nlm.nih.gov/pubmed/28655089
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2017.06.003
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