减低强度预处理异基因造血干细胞移植治疗10例骨髓纤维化患者的临床观察

OBJECTIVE: To evaluate the efficacy of reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-allo-HSCT) for patients with myelofibrosis (MF). METHODS: The clinical data of 10 patients with myelofibrosis (MF) who underwent RIC-allo-HSCT. RESULTS: Of all 10 patients, 6 were male and 4 women, with a median age of 28.5 (22–54). Using fludarabine/busulfan plus total body irradiation (FB+TBI) pretreatment scheme based. Hematopoiesis reconstitution was achieved in 9 patients (90%). The median time of neutrophil and platelet engraftment was 13.5 (10–22) day and 16.5 (13–40) day, respectively. Acute GVHD occurred in 4 cases while chronic GVHD in 5 cases. The prospective OS for 3 years was (90.0±8.5)% after a median follow-up time of 17 months. Transplant related mortality was 1 case. CONCLUSION: RIC-HSCT with FB+TBI is a feasible and effective alternative for MF patients.