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Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo
Yeast DEAD-box helicase Ded1 stimulates translation initiation, particularly of mRNAs with structured 5'UTRs. Interactions of the Ded1 N-terminal domain (NTD) with eIF4A, and Ded1-CTD with eIF4G, subunits of eIF4F, enhance Ded1 unwinding activity and stimulation of preinitiation complex (PIC) a...
Autores principales: | Gulay, Suna, Gupta, Neha, Lorsch, Jon R, Hinnebusch, Alan G |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343385/ https://www.ncbi.nlm.nih.gov/pubmed/32469309 http://dx.doi.org/10.7554/eLife.58243 |
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