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SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

Molecular mimicry is an evolutionary strategy adopted by viruses to exploit the host cellular machinery. We report that SARS-CoV-2 has evolved a unique S1/S2 cleavage site, absent in any previous coronavirus sequenced, resulting in the striking mimicry of an identical FURIN-cleavable peptide on the...

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Detalles Bibliográficos
Autores principales:	Anand, Praveen, Puranik, Arjun, Aravamudan, Murali, Venkatakrishnan, AJ, Soundararajan, Venky
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343387/ https://www.ncbi.nlm.nih.gov/pubmed/32452762 http://dx.doi.org/10.7554/eLife.58603

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