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Resident macrophages acquire innate immune memory in staphylococcal skin infection

Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections. Dermal macrophages (Mφ) are critical for the coordinated defense against invading S. aureus, yet they have a limite...

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Autores principales: Feuerstein, Reinhild, Forde, Aaron James, Lohrmann, Florens, Kolter, Julia, Ramirez, Neftali Jose, Zimmermann, Jakob, Gomez de Agüero, Mercedes, Henneke, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343389/
https://www.ncbi.nlm.nih.gov/pubmed/32639232
http://dx.doi.org/10.7554/eLife.55602
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author Feuerstein, Reinhild
Forde, Aaron James
Lohrmann, Florens
Kolter, Julia
Ramirez, Neftali Jose
Zimmermann, Jakob
Gomez de Agüero, Mercedes
Henneke, Philipp
author_facet Feuerstein, Reinhild
Forde, Aaron James
Lohrmann, Florens
Kolter, Julia
Ramirez, Neftali Jose
Zimmermann, Jakob
Gomez de Agüero, Mercedes
Henneke, Philipp
author_sort Feuerstein, Reinhild
collection PubMed
description Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections. Dermal macrophages (Mφ) are critical for the coordinated defense against invading S. aureus, yet they have a limited life span with replacement by bone marrow derived monocytes. It is currently poorly understood whether localized S. aureus skin infections persistently alter the resident Mφ subset composition and resistance to a subsequent infection. In a strictly dermal infection model we found that mice, which were previously infected with S. aureus, showed faster monocyte recruitment, increased bacterial killing and improved healing upon a secondary infection. However, skin infection decreased Mφ half-life, thereby limiting the duration of memory. In summary, resident dermal Mφ are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection.
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spelling pubmed-73433892020-07-13 Resident macrophages acquire innate immune memory in staphylococcal skin infection Feuerstein, Reinhild Forde, Aaron James Lohrmann, Florens Kolter, Julia Ramirez, Neftali Jose Zimmermann, Jakob Gomez de Agüero, Mercedes Henneke, Philipp eLife Immunology and Inflammation Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections. Dermal macrophages (Mφ) are critical for the coordinated defense against invading S. aureus, yet they have a limited life span with replacement by bone marrow derived monocytes. It is currently poorly understood whether localized S. aureus skin infections persistently alter the resident Mφ subset composition and resistance to a subsequent infection. In a strictly dermal infection model we found that mice, which were previously infected with S. aureus, showed faster monocyte recruitment, increased bacterial killing and improved healing upon a secondary infection. However, skin infection decreased Mφ half-life, thereby limiting the duration of memory. In summary, resident dermal Mφ are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection. eLife Sciences Publications, Ltd 2020-07-08 /pmc/articles/PMC7343389/ /pubmed/32639232 http://dx.doi.org/10.7554/eLife.55602 Text en © 2020, Feuerstein et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Immunology and Inflammation
Feuerstein, Reinhild
Forde, Aaron James
Lohrmann, Florens
Kolter, Julia
Ramirez, Neftali Jose
Zimmermann, Jakob
Gomez de Agüero, Mercedes
Henneke, Philipp
Resident macrophages acquire innate immune memory in staphylococcal skin infection
title Resident macrophages acquire innate immune memory in staphylococcal skin infection
title_full Resident macrophages acquire innate immune memory in staphylococcal skin infection
title_fullStr Resident macrophages acquire innate immune memory in staphylococcal skin infection
title_full_unstemmed Resident macrophages acquire innate immune memory in staphylococcal skin infection
title_short Resident macrophages acquire innate immune memory in staphylococcal skin infection
title_sort resident macrophages acquire innate immune memory in staphylococcal skin infection
topic Immunology and Inflammation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343389/
https://www.ncbi.nlm.nih.gov/pubmed/32639232
http://dx.doi.org/10.7554/eLife.55602
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