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Resident macrophages acquire innate immune memory in staphylococcal skin infection
Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections. Dermal macrophages (Mφ) are critical for the coordinated defense against invading S. aureus, yet they have a limite...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343389/ https://www.ncbi.nlm.nih.gov/pubmed/32639232 http://dx.doi.org/10.7554/eLife.55602 |
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author | Feuerstein, Reinhild Forde, Aaron James Lohrmann, Florens Kolter, Julia Ramirez, Neftali Jose Zimmermann, Jakob Gomez de Agüero, Mercedes Henneke, Philipp |
author_facet | Feuerstein, Reinhild Forde, Aaron James Lohrmann, Florens Kolter, Julia Ramirez, Neftali Jose Zimmermann, Jakob Gomez de Agüero, Mercedes Henneke, Philipp |
author_sort | Feuerstein, Reinhild |
collection | PubMed |
description | Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections. Dermal macrophages (Mφ) are critical for the coordinated defense against invading S. aureus, yet they have a limited life span with replacement by bone marrow derived monocytes. It is currently poorly understood whether localized S. aureus skin infections persistently alter the resident Mφ subset composition and resistance to a subsequent infection. In a strictly dermal infection model we found that mice, which were previously infected with S. aureus, showed faster monocyte recruitment, increased bacterial killing and improved healing upon a secondary infection. However, skin infection decreased Mφ half-life, thereby limiting the duration of memory. In summary, resident dermal Mφ are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection. |
format | Online Article Text |
id | pubmed-7343389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-73433892020-07-13 Resident macrophages acquire innate immune memory in staphylococcal skin infection Feuerstein, Reinhild Forde, Aaron James Lohrmann, Florens Kolter, Julia Ramirez, Neftali Jose Zimmermann, Jakob Gomez de Agüero, Mercedes Henneke, Philipp eLife Immunology and Inflammation Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections. Dermal macrophages (Mφ) are critical for the coordinated defense against invading S. aureus, yet they have a limited life span with replacement by bone marrow derived monocytes. It is currently poorly understood whether localized S. aureus skin infections persistently alter the resident Mφ subset composition and resistance to a subsequent infection. In a strictly dermal infection model we found that mice, which were previously infected with S. aureus, showed faster monocyte recruitment, increased bacterial killing and improved healing upon a secondary infection. However, skin infection decreased Mφ half-life, thereby limiting the duration of memory. In summary, resident dermal Mφ are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection. eLife Sciences Publications, Ltd 2020-07-08 /pmc/articles/PMC7343389/ /pubmed/32639232 http://dx.doi.org/10.7554/eLife.55602 Text en © 2020, Feuerstein et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Immunology and Inflammation Feuerstein, Reinhild Forde, Aaron James Lohrmann, Florens Kolter, Julia Ramirez, Neftali Jose Zimmermann, Jakob Gomez de Agüero, Mercedes Henneke, Philipp Resident macrophages acquire innate immune memory in staphylococcal skin infection |
title | Resident macrophages acquire innate immune memory in staphylococcal skin infection |
title_full | Resident macrophages acquire innate immune memory in staphylococcal skin infection |
title_fullStr | Resident macrophages acquire innate immune memory in staphylococcal skin infection |
title_full_unstemmed | Resident macrophages acquire innate immune memory in staphylococcal skin infection |
title_short | Resident macrophages acquire innate immune memory in staphylococcal skin infection |
title_sort | resident macrophages acquire innate immune memory in staphylococcal skin infection |
topic | Immunology and Inflammation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343389/ https://www.ncbi.nlm.nih.gov/pubmed/32639232 http://dx.doi.org/10.7554/eLife.55602 |
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