SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair

When transcribed DNA is damaged, the transcription and DNA repair machineries must interact to ensure successful DNA repair. The mechanisms of this interaction in the context of chromatin are still being elucidated. Here we show that the SIRT6 protein enhances non-homologous end joining (NHEJ) DNA r...

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Detalles Bibliográficos
Autores principales: Rezazadeh, Sarallah, Yang, David, Biashad, Seyed Ali, Firsanov, Denis, Takasugi, Masaki, Gilbert, Michael, Tombline, Gregory, Bhanu, Natarajan V., Garcia, Benjamin A., Seluanov, Andrei, Gorbunova, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343504/
https://www.ncbi.nlm.nih.gov/pubmed/32584788
http://dx.doi.org/10.18632/aging.103567

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