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Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age

Advanced age is accompanied by aortic stiffening that is associated with decreased vascular expression of sirtuin-1 (SIRT-1). Interventions that increase SIRT-1 expression also lower age-related aortic stiffness. Therefore, we sought to determine if lifelong SIRT-1 overexpression would attenuate age...

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Detalles Bibliográficos
Autores principales:	Machin, Daniel R., Auduong, Yauling, Gogulamudi, Venkateswara R., Liu, Yu, Islam, Md. Torikul, Lesniewski, Lisa A., Donato, Anthony J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343505/ https://www.ncbi.nlm.nih.gov/pubmed/32564006 http://dx.doi.org/10.18632/aging.103322

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