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Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists
Since its initial recognition in December 2019, Coronavirus disease 19 (COVID-19) has quickly spread to a pandemic infectious disease. The causative agent has been recognized as a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affecting the respiratory tra...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343579/ https://www.ncbi.nlm.nih.gov/pubmed/32642842 http://dx.doi.org/10.1007/s00428-020-02886-6 |
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author | Calabrese, Fiorella Pezzuto, Federica Fortarezza, Francesco Hofman, Paul Kern, Izidor Panizo, Angel von der Thüsen, Jan Timofeev, Sergei Gorkiewicz, Gregor Lunardi, Francesca |
author_facet | Calabrese, Fiorella Pezzuto, Federica Fortarezza, Francesco Hofman, Paul Kern, Izidor Panizo, Angel von der Thüsen, Jan Timofeev, Sergei Gorkiewicz, Gregor Lunardi, Francesca |
author_sort | Calabrese, Fiorella |
collection | PubMed |
description | Since its initial recognition in December 2019, Coronavirus disease 19 (COVID-19) has quickly spread to a pandemic infectious disease. The causative agent has been recognized as a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affecting the respiratory tract. To date, no vaccines are available nor any specific treatment. To limit the number of infections, strict directives have been issued by governments that have been translated into equally rigorous guidelines notably for post-mortem examinations by international and national scientific societies. The recommendations for biosafety control required during specimen collection and handling have strongly limited the practice of autopsies of the COVID-19 patients to a few adequate laboratories. A full pathological examination has always been considered an important tool to better understand the pathophysiology of diseases, especially when the knowledge of an emerging disorder is limited and the impact on the healthcare system is significant. The first evidence of diffuse alveolar damage in the context of an acute respiratory distress syndrome has now been joined by the latest findings that report a more complex scenario in COVID-19, including a vascular involvement and a wide spectrum of associated pathologies. Ancillary tools such as electron microscopy and molecular biology used on autoptic tissue samples from autopsy are also significantly contributing to confirm and/or identify new aspects useful for a deeper knowledge of the pathogenetic mechanisms. This article will review and summarize the pathological findings described in COVID-19 until now, chiefly focusing on the respiratory tract, highlighting the importance of autopsy towards a better knowledge of this disease. |
format | Online Article Text |
id | pubmed-7343579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-73435792020-07-09 Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists Calabrese, Fiorella Pezzuto, Federica Fortarezza, Francesco Hofman, Paul Kern, Izidor Panizo, Angel von der Thüsen, Jan Timofeev, Sergei Gorkiewicz, Gregor Lunardi, Francesca Virchows Arch Review and Perspectives Since its initial recognition in December 2019, Coronavirus disease 19 (COVID-19) has quickly spread to a pandemic infectious disease. The causative agent has been recognized as a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affecting the respiratory tract. To date, no vaccines are available nor any specific treatment. To limit the number of infections, strict directives have been issued by governments that have been translated into equally rigorous guidelines notably for post-mortem examinations by international and national scientific societies. The recommendations for biosafety control required during specimen collection and handling have strongly limited the practice of autopsies of the COVID-19 patients to a few adequate laboratories. A full pathological examination has always been considered an important tool to better understand the pathophysiology of diseases, especially when the knowledge of an emerging disorder is limited and the impact on the healthcare system is significant. The first evidence of diffuse alveolar damage in the context of an acute respiratory distress syndrome has now been joined by the latest findings that report a more complex scenario in COVID-19, including a vascular involvement and a wide spectrum of associated pathologies. Ancillary tools such as electron microscopy and molecular biology used on autoptic tissue samples from autopsy are also significantly contributing to confirm and/or identify new aspects useful for a deeper knowledge of the pathogenetic mechanisms. This article will review and summarize the pathological findings described in COVID-19 until now, chiefly focusing on the respiratory tract, highlighting the importance of autopsy towards a better knowledge of this disease. Springer Berlin Heidelberg 2020-07-09 2020 /pmc/articles/PMC7343579/ /pubmed/32642842 http://dx.doi.org/10.1007/s00428-020-02886-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review and Perspectives Calabrese, Fiorella Pezzuto, Federica Fortarezza, Francesco Hofman, Paul Kern, Izidor Panizo, Angel von der Thüsen, Jan Timofeev, Sergei Gorkiewicz, Gregor Lunardi, Francesca Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists |
title | Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists |
title_full | Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists |
title_fullStr | Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists |
title_full_unstemmed | Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists |
title_short | Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists |
title_sort | pulmonary pathology and covid-19: lessons from autopsy. the experience of european pulmonary pathologists |
topic | Review and Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343579/ https://www.ncbi.nlm.nih.gov/pubmed/32642842 http://dx.doi.org/10.1007/s00428-020-02886-6 |
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