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Extracellular serine controls epidermal stem cell fate and tumor initiation
Tissue stem cells are the cell of origin for many malignancies. Metabolites regulate the balance between self-renewal and differentiation, but whether endogenous metabolic pathways or nutrient availability predispose stem cells to transformation remains unknown. Here, we address this question in epi...
Autores principales: | Baksh, Sanjeethan C, Todorova, Pavlina K, Gur-Cohen, Shiri, Hurwitz, Brian, Ge, Yejing, Novak, Jesse S S, Tierney, Matthew T, Racelis, June, Fuchs, Elaine, Finley, Lydia W S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343604/ https://www.ncbi.nlm.nih.gov/pubmed/32451440 http://dx.doi.org/10.1038/s41556-020-0525-9 |
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