Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Cas9 is commonly introduced into cell lines to enable CRISPR/Cas9-mediated genome editing. Here we studied the genetic and transcriptional consequences of Cas9 expression per se. Gene expression profiling of 165 pairs of human cancer cell lines and their Cas9-expressing derivatives revealed upregula...

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Detalles Bibliográficos
Autores principales: Enache, Oana M., Rendo, Veronica, Abdusamad, Mai, Lam, Daniel, Davison, Desiree, Pal, Sangita, Currimjee, Naomi, Hess, Julian, Pantel, Sasha, Nag, Anwesha, Thorner, Aaron R., Doench, John G., Vazquez, Francisca, Beroukhim, Rameen, Golub, Todd R., Ben-David, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343612/
https://www.ncbi.nlm.nih.gov/pubmed/32424350
http://dx.doi.org/10.1038/s41588-020-0623-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343612/
https://www.ncbi.nlm.nih.gov/pubmed/32424350
http://dx.doi.org/10.1038/s41588-020-0623-4

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