Cargando…

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Cas9 is commonly introduced into cell lines to enable CRISPR/Cas9-mediated genome editing. Here we studied the genetic and transcriptional consequences of Cas9 expression per se. Gene expression profiling of 165 pairs of human cancer cell lines and their Cas9-expressing derivatives revealed upregula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Enache, Oana M., Rendo, Veronica, Abdusamad, Mai, Lam, Daniel, Davison, Desiree, Pal, Sangita, Currimjee, Naomi, Hess, Julian, Pantel, Sasha, Nag, Anwesha, Thorner, Aaron R., Doench, John G., Vazquez, Francisca, Beroukhim, Rameen, Golub, Todd R., Ben-David, Uri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343612/ https://www.ncbi.nlm.nih.gov/pubmed/32424350 http://dx.doi.org/10.1038/s41588-020-0623-4

Ejemplares similares

DIPG-54. p53 pathway reactivation as a therapeutic strategy in diffuse intrinsic pontine glioma
por: Lupien, Leslie, et al.
Publicado: (2022)

p53 isoforms change p53 paradigm
por: Bourdon, JC
Publicado: (2014)

The MDM2-p53 pathway revisited
por: Nag, Subhasree, et al.
Publicado: (2013)

HGG-32. UNCOVERING THERAPEUTIC VULNERABILITIES IN MISMATCH REPAIR-DEFICIENT GLIOMAS
por: Boynton, Adam, et al.
Publicado: (2020)

Oscillations and variability in the p53 system
por: Geva-Zatorsky, Naama, et al.
Publicado: (2006)

p53 β-hydroxybutyrylation attenuates p53 activity
por: Liu, Kun, et al.
Publicado: (2019)

Understanding p53 functions through p53 antibodies
por: Sabapathy, Kanaga, et al.
Publicado: (2019)

p53’s Extended Reach: The Mutant p53 Secretome
por: Pavlakis, Evangelos, et al.
Publicado: (2020)

D133P53, directly transactivated by p53, prevents p53-mediated apoptosis without inhibiting p53-mediated cell cycle arrest
por: Aoubala, M, et al.
Publicado: (2010)

OTUD5 Regulates p53 Stability by Deubiquitinating p53
por: Luo, Judong, et al.
Publicado: (2013)

The Δ133p53 Isoforms, Tuners of the p53 Pathway
por: Joruiz, Sebastien M., et al.
Publicado: (2020)

Corrigendum to ‘Understanding p53 functions through p53 antibodies’
por: Sabapathy, Kanaga, et al.
Publicado: (2019)

Expression of TP53 Isoforms p53β or p53γ Enhances Chemosensitivity in TP53(null) Cell Lines
por: Silden, Elisabeth, et al.
Publicado: (2013)

HPV infection and p53 inactivation in pterygium
por: Tsai, Yi-Yu, et al.
Publicado: (2009)

Tanning with p53
por: Williams, Ruth
Publicado: (2007)

PINTing for p53
por: Shiekhattar, Ramin
Publicado: (2013)

p53 Dysregulation in Breast Cancer: Insights on Mutations in the TP53 Network and p53 Isoform Expression
por: Steffens Reinhardt, Luiza, et al.
Publicado: (2023)

Updates on p53: modulation of p53 degradation as a therapeutic approach
por: Dey, A, et al.
Publicado: (2008)

Targeting p53 by small molecule p53 activators in multiple myeloma
por: Saha, Manujendra N, et al.
Publicado: (2012)

Mutations in p53, p53 protein overexpression and breast cancer survival
por: Rossner, Pavel, et al.
Publicado: (2009)

Role of p53 Serine 46 in p53 Target Gene Regulation
por: Smeenk, Leonie, et al.
Publicado: (2011)

Δ113p53/Δ133p53: survival and integrity
por: Chen, Jun, et al.
Publicado: (2015)

Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness
por: Olivos, David J., et al.
Publicado: (2016)

p53 tetramerization: at the center of the dominant-negative effect of mutant p53
por: Gencel-Augusto, Jovanka, et al.
Publicado: (2020)

D133p53 isoform is a direct p53 target gene that modulates p53 tumour suppressor activity
por: Aoubala, M
Publicado: (2008)

Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner
por: Wamsley, J J, et al.
Publicado: (2017)

Cancer-derived p53 mutants suppress p53-target gene expression—potential mechanism for gain of function of mutant p53
por: Vikhanskaya, Faina, et al.
Publicado: (2007)

Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene.
por: Gorgoulis, V. G., et al.
Publicado: (1998)

Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53
por: Hafsi, Hind, et al.
Publicado: (2013)

Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function
por: Shen, Jia, et al.
Publicado: (2014)

p53 Status in Multiple Human Urothelial Cancers: Assessment for Clonality by the Yeast p53 Functional Assay in Combination with p53 Immunohistochemistry
por: Yamamoto, Shinji, et al.
Publicado: (2000)

C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo
por: Fine, Robert L., et al.
Publicado: (2023)

Antitumor mechanisms when pRb and p53 are genetically inactivated
por: Zhu, Liang, et al.
Publicado: (2014)

p53 protein overexpression and allele loss of p53 gene in gastric adenocarcinoma.
por: Choi, S. W., et al.
Publicado: (1994)

p53 continues to surprise: High levels of p53 can suppress apoptosis
por: Callen, David F.
Publicado: (2013)

Polymorphisms in p53 and the p53 pathway: roles in cancer susceptibility and response to treatment
por: Hrstka, Roman, et al.
Publicado: (2009)

p53 Aggregates Penetrate Cells and Induce the Co-Aggregation of Intracellular p53
por: Forget, Karolyn J., et al.
Publicado: (2013)

Serum p53 Antibody Is Not Associated with p53 Immunoreactivity in Patients with Pancreatobiliary Cancers
por: Umeda, Junko, et al.
Publicado: (2013)

The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis
por: Shen, Jia, et al.
Publicado: (2014)

Targeting the P53 Protein for Cancer Therapies: The Translational Impact of P53 Research
por: Levine, Arnold J.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r2dau52qrn753scaookp8ih189