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Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases
Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal evolution and impact of treatment are poorly understood. We analyzed whole-exome sequencing data from 457 paired primary tumor and metastatic samples from 136 breast, colorectal and lung cancer patients, includ...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343625/ https://www.ncbi.nlm.nih.gov/pubmed/32424352 http://dx.doi.org/10.1038/s41588-020-0628-z |